Correlation between ZBRK1/ZNF350 gene polymorphism and breast cancer

BMC Medical Genomics

Table 1 ZBRK1/ZNF350 gene exon mutations and function prediction (case group)

SNP No	Nucleotide change	SNP site	Location	Amino acid change	Mutation type	SIFT protein change	SIFT Prediction score
1	c.105 T > C	rs4986773	EXON3	p.Asp35Asp	S	No effect	-
2	c.111G > A	rs4987241	EXON3	p.Met37Ile	M	Impairment	0.00
3	c.197 T > C	rs2278420	EXON4	p.Leu66Pro	M	Neutral	0.47
4	c.708 T > C	rs4988334	EXON5	p.Cys236Cys	S	No effect	-
5	c.1119C > A	rs3764538	EXON5	p.Pro373Pro	S	No effect	-
6	c.1503A > T	rs2278415	EXON5	p.Arg501Ser	M	Impairment	0.04
7	c.1155A > C	rs4986772	EXON5	p.Thr385Thr	S	No effect	-
8	c.1414 T > C	rs4986771	EXON5	p.Ser472Pro	M	Neutral	0.10
9	c.100C > T	rs138898320	EXON3	p.Arg34Trp	M	Neutral	0.09

The SIFT prediction score < 0.05 indicated that it affected the protein function. S, synonymous mutation; and M, missense mutation

ISSN: 1755-8794