Correlation analysis of IL-11 polymorphisms and Hirschsprung disease subtype susceptibility in Southern Chinese Children

Table 1 Patient-only associations of IL-11 SNPs with HSCR Enteritis stratification

SNP	A1/A2	E_before operation_SHCSR				E_before operation_LHCSR				E_before operation_TCA
SNP	A1/A2	F_A	F_U	P	OR	F_A	F_U	P	OR	F_A	F_U	P	OR
rs8104023	C/T	0.02	0.01	0.02	4.05 (1.18–13.93)	0	0.03	0.03	NA	0	0	NA	NA
rs4252546	T/C	0.26	0.27	0.71	0.94 (0.70–1.28)	0.26	0.23	0.57	1.17 (0.68 ~ 2.02)	0.20	0.17	0.68	1.29 (0.38 ~ 4.30)

		E_after operation_SHCSR				E_after operation_LHCSR				E_after operation_TCA
rs8104023	C/T	0.02	0.01	0.04	3.34 (1.01–11.04)	0.00	0.03	0.03	NA	0.00	0.00	NA	NA
rs4252546	T/C	0.25	0.27	0.49	0.90 (0.66–1.23)	0.22	0.28	0.25	0.73 (0.43–1.25)	0.18	0.31	0.19	0.49 (0.17–1.44)

SNP, Single Nucleotide Polymorphism; A1/A2 indicates the risk-allele and protective allele to disease; F_A/F_U indicates risk-allele frequency of the SNP in cases or controls; SHSCR, short-segment HSCR; L-HSCR, long-segment HSCR; TCA, total colon aganglionosis; The P-value indicates the significance based on allelic association tests; The calculation of odds ratio (OR) is also based on the risk-allele of each SNP

ISSN: 1755-8794