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Table 2 Fractions of all hypermethylated and non-differentially methylated probes in the TCGA DNA methylation dataset for UPUP-only and UPDOWN-only regulation pattern groups, where probes are located in different genomic regions: 3’UTR, 5’UTR, coding exons, exons and introns of the associated genes. Furthermore, fractions of probes that are specifically located in the first coding exon, first exon and first intron is also shown

From: DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation

Region UPUP-only UPDOWN-only
  Part of all hypermethylated probes located in a specific region Part of all non-differentially methylated probes located in a specific Part of all hypermethylated probes located in a specific region Part of all non-differentially methylated probes located in a specific
3’UTR 9.66% (94 probes) 8.53% (36 probes) 7.02% (131 probes) 11.61% (88 probes)
5’UTR 14.25% (130 probes) 13.92% (55 probes 16.14% (297 probes) 13.72% (104 probes)
Coding exons 18.41% (181 probes) 17.26% (73 probes) 14.16% (266 probes) 14.19% (108 probes)
Exons 39.25% (389 probes) 36.49% (158 probes) 35.36% (664 probes) 35.09% (267 probes)
Introns 26.80% (194 probes) 24.57% (86 probes) 26.91% (465 probes) 32.47% (225 probes)
  Part of all hypermethylated probes in any coding exon/exon/intron Part of all non-differentially methylated probes in any coding exon/exon/intron Part of all hypermethylated probes in any coding exon/exon/intron Part of all non-differentially methylated probes in any coding exon/exon/intron
First coding exon 64% (116 probes) 72.60% (53 probes) 63.53% (169 probes) 55.55% (60 probes)
First exon 66.84% (260 probes) 61.39% (97 probes) 70.03% (465 probes) 55.06% (147 probes)
First intron 70.62% (137 probes) 69.77% (60 probes) 79.14% (368 probes) 63.11% (142 probes)