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Table 2 Summary of mutation status of seven DNA methylation modifier genes in each cancer

From: Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

Cancer type

Total samples

Mutated samples

Non-mutated samples

Mutation sample ratio

Number of DMRs

Number of DEGs

TCGA-BRCA

784

47

737

6%

20,390

99

TCGA-HNSC

521

41

480

8%

21,442

57

TCGA-LUAD

455

66

389

15%

7,886

288

TCGA-BLCA

408

70

338

17%

12,711

379

TCGA-LUSC

369

55

314

15%

45,441

415

TCGA-KIRC

319

17

302

5%

23,544

127

TCGA-COAD

279

54

225

19%

26,491

535

TCGA-UCEC

173

37

136

21%

44,743

1,494

TCGA-LAML

170

33

137

19%

28,215

439

TCGA-READ

93

8

85

9%

58,058

205

TCGA-GBM

64

4

60

6%

77,753

215

  1. Each value represents the number of samples that have both methylome and transcriptome data, the number of samples that have mutations in seven DNA methylation modifier genes, the number of samples that don’t have mutations, ratio of the mutation samples per non-mutation samples, the number of DMRs and the number of DEGs that were selected by 0.05 false discovery rate