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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer

Fig. 2

Spectrum of Apoptosis Regulations By IAPs. Gene set enrichment analysis identified different mechanisms for apoptosis regulations by different IAPs in different cancers (a) through three major apoptosis pathways including the extrinsic pathway of apoptosis (25 genes), the intrinsic pathway of apoptosis (36 genes) and the execution phase of apoptosis (47 genes) as depicted in (b). Percentage value on top of (a) summarized the proportion of cancers with at least one apoptosis pathways being regulated by a given IAP. The right hand bars on (a) summarized number of apoptosis pathways being regulated in each cancer. The intrinsic pathway of apoptosis (35.7%) as well as the extrinsic pathway of apoptosis (29.0%) were more frequently regulated by IAPs than the execution phase of apoptosis (18.3%) across all cancers. Here percentages were computed across all cancer-IAP regulation pairs. The frequency of apoptosis pathway regulations varied among different IAPs, with BIRC3 and BIRC6 both regulating 36.4% of cancers while BIRC7 only regulating 12.5% of cancers through at least one of the apoptosis pathways. Enriched pathways were identified with adjusted p value less than 0.05

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