Fig. 3

Global Pathways Regulated By IAPs. a Our analysis revealed extensive enriched pathways by IAPs beyond apoptosis including immune system, cell cycle, transcription and translation of genes, signal transduction, and DNA damage repair. Green dotted box highlighted the fact that BIRC3 mostly exerted regulations through the immune system containing interferon signaling, TCR signaling, PD-1 signaling and cytokine signaling pathways. The red dotted box highlighted that BIRC5, BIRC6 and XIAP were heavily involved in cell cycle pathways, signal transduction and DNA damage repair (red arrows). Additionally, NAIP, BIRC2, BIRC5, XIAP and BIRC6 were heavily involved in transcription and translation of genes. b Orchestrated REST and IAPs expression. BIRC5 and BIRC7 were negatively correlated with REST expression while other IAPs were positively correlated with REST expression in multiple cancers. For example, BIRC6 and XIAP were significantly positively correlated with REST expression across all cancer types except XIAP in PCPG. All of the 7 IAPs were significantly associated with REST in 5 cancer types, including PRAD, PAAD, HNSC, SARC, LGG. Each of the cancer types had at least 2 IAPs that correlated with REST expression