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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer

Fig. 4

Oncogenic and Anti-oncogenic Roles of IAPs. Global comparison of IAPs expression between tumor and adjacent normal tissues across different cancers demonstrated that IAPs had extensive oncogenic or anti-oncogenic roles (a). A detailed visualization of BIRC5 and BIRC7 was provided in (b) and (c). In particular, BIRC5 was significantly overexpressed in 94% of the cancers followed by BIRC7 which was overexpressed in 66% of the cancers. Unlike BIRC5 and BIRC7 which demonstrated a strong oncogenic role, BIRC6 was down-regulated in eight human cancers compared to adjacent normal tissue. The differential expression of NAIP, BIRC2, BIRC3 and XIAP were cancer-type specific

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