Skip to main content
Fig. 8 | BMC Medical Genomics

Fig. 8

From: Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer

Fig. 8

Global Landscape of Chemosensitivity Associated with IAPs using preclinical cell line data. Expanding our analysis to all the 250 drugs profiled by GDSC, we obtained a global landscape of chemosensitivity associated with IAPs expression. Focusing on the drugs that were most frequently associated with drug sensitivity, we identified 10 drugs targeting 5 major pathways including EGFR signaling, ERK MAPK signaling, genome integrity, PI3K/MTOR signaling, and WNT signaling. Narrower bars indicate positive correlation (higher expression predicting resistance). For example, yellow dotted bar represented LCML cell lines with high BIRC7 expression being resistant to Pelitinib, an inhibitor to EGFR signaling. Wider bars indicate negative correlation (higher expression predicting sensitivity). For example, purple dotted bar represented ESCA cell lines with high BIRC3 expression was sensitive to Pictilisib, an inhibitor to the PI3K/MTOR signaling pathway. There were six cancers (LGG, GBM, NB, LAML, HNSC, READ) on the left of the figure (red dotted box) where IAPs expression was mostly associated with drug resistance and nine cancers (SCLC, LUAD, LUSC, THCA, CESC, SKCM, KIRC, BRCA, OV) on the right (green dotted box) where IAPs expression was associated with drug sensitivity. Blue dotted box circling the top column bar summarized sensitivity to seven drugs when BIRC3 expression was high, and resistance to one drug when BIRC2 expression was high in THCA

Back to article page