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Fig. 4 | BMC Medical Genomics

Fig. 4

From: An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer

Fig. 4

The functional impact of rs72635708. a At the top, the layered ChIP-seq signals of H3K4me3, H3K4me1, and H3K27ac are shown. At the middle, ChromHMM annotation (25-STATE MODEL) for various tissues and cells is shown. At the bottom, ChIP-seq density signals of various proteins for the HepG2 cell line are shown. The location of rs72635708 is indicated by a vertical red line. b The sequence logos based on the position weight matrix of binding sites for Bach1::Mafk (MA0591.1), FOS (MA0476.1), and JUND (MA0491.1) are represented with genomic sequences. The location of rs72635708 is indicated by a dotted box. c Comparison of ERRFI1 expression levels among rs72635708 genotypes in the liver and fibroblasts. The plots were generated by the GTEx project. The horizontal axis shows genotypes with the number of individuals in parentheses. The asterisk indicates statistical significance

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BMC Medical Genomics

ISSN: 1755-8794

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