Fig. 5

A model for the regulation of ERRFI1 promoter activity by a long-range enhancer. Chromatin illustrations were obtained from the TogoPictureGallery (https://togotv.dbcls.jp/togopic.2017.10.html). a With a protective allele (rs72635708-T), the AP-1 complex can bind to the enhancer element. This leads to chromatin remodeling around the element, resulting in the stable expression of ERRFI1. b With a risk allele (rs72635708-C), the binding levels of the AP-1 complex to the enhancer element are reduced so that chromatin accessibility might not be enough to be activated by other TFs. This results in the unstable expression of ERRFI1