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Table 2 Candidate functional variants in promoters associated with psoriasis risk

From: An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer

Chr. Position Variant Alleles (P/R) RAF Gene TF Marker (P-value, Study) r2
6 31,371,100 rs6906175 G/C 0.2952 MICA REST rs13437088 (3.00E-40, [25]) 1.0000
6 31,430,009 rs3132089 (G/A)? NR HCP5 ARNT, BHLHE40 rs3134792 (1.00E-09, [18]) 0.9253
6 31,462,134 rs3130923 (G/A)? NR MICB TCF3 rs3134792 (1.00E-09, [18]) 0.8762
12 56,728,257 rs11358218 A/− 0.9304 PAN2 SPI1 rs2066807 (5.00E-12, [27]) 0.9541
        rs2066808 (6.00E-10, [26]) 1.0000
        rs2066819 (5.00E-17, [25]) 0.8933
16 30,968,588 rs4889599 C/T 0.3658 SETD1A EGR1 rs10782001 (9.00E-10, [22]) 0.9703
        rs12445568 (1.00E-16, [25]) 0.8876
        rs13708 (2.00E-08, [27]) 0.9915
20 43,989,513 rs2741432 G/A 0.7744 SYS1 CEBPB rs1008953 (1.00E-07, [22]) 0.9943
  1. As for rs3134792 and its functional variants, the direction of effects is unknown
  2. P/R protective/risk, RAF risk allele frequency, NR not reported, TF transcription factor, r2 r-squared value between functional variants and GWAS variants