An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer

Table 2 Candidate functional variants in promoters associated with psoriasis risk

Chr.	Position	Variant	Alleles (P/R)	RAF	Gene	TF	Marker (P-value, Study)	r²
6	31,371,100	rs6906175	G/C	0.2952	MICA	REST	rs13437088 (3.00E-40, [25])	1.0000
6	31,430,009	rs3132089	(G/A)?	NR	HCP5	ARNT, BHLHE40	rs3134792 (1.00E-09, [18])	0.9253
6	31,462,134	rs3130923	(G/A)?	NR	MICB	TCF3	rs3134792 (1.00E-09, [18])	0.8762
12	56,728,257	rs11358218	A/−	0.9304	PAN2	SPI1	rs2066807 (5.00E-12, [27])	0.9541
							rs2066808 (6.00E-10, [26])	1.0000
							rs2066819 (5.00E-17, [25])	0.8933
16	30,968,588	rs4889599	C/T	0.3658	SETD1A	EGR1	rs10782001 (9.00E-10, [22])	0.9703
							rs12445568 (1.00E-16, [25])	0.8876
							rs13708 (2.00E-08, [27])	0.9915
20	43,989,513	rs2741432	G/A	0.7744	SYS1	CEBPB	rs1008953 (1.00E-07, [22])	0.9943

As for rs3134792 and its functional variants, the direction of effects is unknown
P/R protective/risk, RAF risk allele frequency, NR not reported, TF transcription factor, r² r-squared value between functional variants and GWAS variants

ISSN: 1755-8794