Skip to main content
Fig. 8 | BMC Medical Genomics

Fig. 8

From: AMLVaran: a software approach to implement variant analysis of targeted NGS sequencing data in an oncological care setting

Fig. 8

Results for validated mutations in the AML-1 dataset. The graphic shows the total number of validated samples per variant as a black outline. The number of true positive detections by AMLVaran is visualized in green, and the number of validated true variants that were missed by the program are indicated in pale red. The remaining white part of the bar charts indicate positions without calls in AMLVaran, which were confirmed to be wild-type alleles. There were no false positive detections. a NPM1: n=75, Detected =40/42, Sensitivity =0.9524, PPV =1.0000. b JAK2: n=10, Detected =6/6, Sensitivity =1.0000, PPV =1.0000. c FLT3_TKD: n=50, Detected =5/6, Sensitivity =0.8333, PPV =1.0000. d CEBPA: n=30, Detected =2/3, Sensitivity =0.6667, PPV =1.0000

Back to article page