Table 1 Accumulated numbers of variants in hotspot regions detected by AMLVaran in comparison with appreci8 reference implementation
| Â | MDS-1 (n=237, #Mut=195) | MDS-2 (n=46, #Mut=52) | AML-1 (n=119, #Mut=172) | |||
|---|---|---|---|---|---|---|
| Â | appreci8 | AMLVaran | appreci8 | AMLVaran | appreci8 | AMLVaran |
Called variants | 193 | 194 | 52 | 52 | 172 | 171 |
True positives | 193 | 193 | 52 | 52 | 172 | 171 |
False positives | 0 | 1 | 0 | 0 | 0 | 0 |
Sensitivity | 0.9897 | 0.9897 | 1.0000 | 1.0000 | 1.0000 | 0.9942 |
PPV | 1.0000 | 0.9948 | 1.0000 | 1.0000 | 1.0000 | 1.0000 |