Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals

BMC Medical Genomics

Table 2 Differentially methylation positions identified between individuals with CD and non-affected controls

hg19 coordinates	Probe	Associated Gene	Genomic Position	Adj. P Value	Δβ
Hypomethylated
chr19:14142585	cg06860352	IL27RA	5’UTR	p < 0.05	−0.01
chr8:2060933	cg05570806	MYOM2	Body	p < 0.05	− 0.01
chr8:128748337	cg03076047	MYC	5’UTR	p < 0.05	− 0.02
chr7:97923044	cg27013914	BAIAP2L1	Body	p < 0.05	−0.02
chr2:11864427	cg15380473			p < 0.05	−0.02
chr19:649301	cg18811158	RNF126	Body	p < 0.05	−0.02
chr17:45907760	cg12380854	LRRC46;MRPL10	TSS1500	p < 0.05	−0.02
chr10:135141628	cg11126081	CALY	Body	p < 0.05	−0.03
chr11:33334443	cg26400421	HIPK3	Body	p < 0.05	−0.03
chr5:156516798	cg19063654	HAVCR2	Body	p < 0.05	−0.04
chr16:6976709	cg16716449	A2BP1	5’UTR	p < 0.05	−0.10
Hypermethylated
chr12:30251537	cg09151187			p < 0.05	0.03
chr14:68283333	cg12952552	ZFYVE26	TSS1500	p < 0.05	0.01
chr17:61920550	cg04367190	SMARCD2	TSS1500	p < 0.05	0.01
chr6:7389895	cg05371005	CAGE1;RIOK1	5’UTR	p < 0.05	0.01
chr6:26027625	cg12474759	HIST1H4B	TSS1500	p < 0.05	0.01
chr3:112738652	cg05582165	C3orf17	TSS1500	p < 0.05	0.01
chr11:14542136	cg12352359	PSMA1	TSS1500	p < 0.05	0.01
chr10:81741832	cg18762849			p < 0.05	0.01
chr13:52586133	cg18796523	ALG11;ATP7B	TSS1500	p < 0.05	0.01

TSS = 200–1500 bases upstream of transcription start site, 5’UTR = 5′ – untranslated region upstream from initiation codon, Body = body of gene. Positive Δβ values indicate hypermethylation in individuals with CD; negative Δβ values indicate hypomethylation in individuals with CD

ISSN: 1755-8794