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Table 2 Differentially methylation positions identified between individuals with CD and non-affected controls

From: Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals

hg19 coordinatesProbeAssociated GeneGenomic PositionAdj. P ValueΔβ
Hypomethylated
 chr19:14142585cg06860352IL27RA5’UTRp < 0.05−0.01
 chr8:2060933cg05570806MYOM2Bodyp < 0.05− 0.01
 chr8:128748337cg03076047MYC5’UTRp < 0.05− 0.02
 chr7:97923044cg27013914BAIAP2L1Bodyp < 0.05−0.02
 chr2:11864427cg15380473  p < 0.05−0.02
 chr19:649301cg18811158RNF126Bodyp < 0.05−0.02
 chr17:45907760cg12380854LRRC46;MRPL10TSS1500p < 0.05−0.02
 chr10:135141628cg11126081CALYBodyp < 0.05−0.03
 chr11:33334443cg26400421HIPK3Bodyp < 0.05−0.03
 chr5:156516798cg19063654HAVCR2Bodyp < 0.05−0.04
 chr16:6976709cg16716449A2BP15’UTRp < 0.05−0.10
Hypermethylated
 chr12:30251537cg09151187  p < 0.050.03
 chr14:68283333cg12952552ZFYVE26TSS1500p < 0.050.01
 chr17:61920550cg04367190SMARCD2TSS1500p < 0.050.01
 chr6:7389895cg05371005CAGE1;RIOK15’UTRp < 0.050.01
 chr6:26027625cg12474759HIST1H4BTSS1500p < 0.050.01
 chr3:112738652cg05582165C3orf17TSS1500p < 0.050.01
 chr11:14542136cg12352359PSMA1TSS1500p < 0.050.01
 chr10:81741832cg18762849  p < 0.050.01
 chr13:52586133cg18796523ALG11;ATP7BTSS1500p < 0.050.01
  1. TSS = 200–1500 bases upstream of transcription start site, 5’UTR = 5′ – untranslated region upstream from initiation codon, Body = body of gene. Positive Δβ values indicate hypermethylation in individuals with CD; negative Δβ values indicate hypomethylation in individuals with CD
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BMC Medical Genomics

ISSN: 1755-8794

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