Table 3 Top differentially methylated regions (DMRs) identified between CD individuals and non-affected controls (|Δβ| > 5%, p < 0.05)
hg19 Coordinates | No. of Probes | Associated Gene | Δβ |
|---|---|---|---|
Hypomethylated | |||
 chr6:33053576–33,054,001 | 5 | HLA-DPB1 | −0.08 |
 chr2:113190072–113,190,197 | 2 | RGPD8 | −0.07 |
 chr2:130794753–130,795,678 | 4 | FAR2P1 | −0.06 |
 chr20:623089–623,421 | 4 | SRXN1 | −0.06 |
 chr7:100343083–100,343,110 | 2 | ZAN | −0.05 |
 chr6:31275148–31,276,797 | 24 | HLA-B | −0.05 |
 chr15:29034942–29,034,950 | 2 | PDCD6IPP2 | −0.05 |
Hypermethylated | |||
 chr1:246667857–246,668,601 | 2 | SMYD3 | 0.13 |
 chr17:6557720–6,558,815 | 6 | MIR4520–2 | 0.09 |
 chr15:41098188–41,100,308 | 14 | ZFYVE19 | 0.07 |
 chr6:32632694–32,633,163 | 8 | HLA-DQB1 | 0.06 |
 chr6:25882328–25,882,590 | 5 | SLC17A3 | 0.05 |
 chr11:288301–288,305 | 2 | ATHL1 | 0.05 |
 chr5:77146796–77,147,141 | 3 | TBCA | 0.05 |
 chr14:24779400–24,780,926 | 14 | LTB4R2 | 0.05 |