Fig. 4

Histogram of neutrophil-related significant changes in gene expression between severe influenza, moderate influenza illness and healthy controls. Y-axis shows normalised log₂ expression levels. * indicate p < 0.001, adjusted for multiple testing by Bonferroni method. ns denotes non-significant. HC denotes healthy control. a Genes encoding proteins involved in neutrophil extracellular trap formation. Expression differences are shown for (the strongest regulated) probesets of the individual gene. b Genes encoding proteins involved in neutrophil migration. Expression differences are shown for (the strongest regulated) probesets of the individual gene. c Genes encoding components of neutrophil granules. Expression differences are shown for (the strongest regulated) probesets of the individual gene. Neutrophils-related genes were upregulated in patients with severe influenza illness compared to moderate influenza illness and healthy control subjects