Fig. 5

Histogram of MHC class II significant changes in gene expression between severe influenza compared to moderate influenza illness and healthy controls. Expression differences are shown for (the strongest regulated) probesets of the individual gene. Y-axis shows normalised log₂ expression levels. * indicate p < 0.001, adjusted for multiple testing by Bonferroni method. ns denotes non-significant. HC denotes healthy control MHC class II were downregulated in patients with severe influenza illness compared to moderate influenza illness and healthy control subjects