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Table 1 Demographics and clinical characteristics of patients

From: Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection

 Healthy Controls
n = 52
Moderate
n = 63
Severe
n = 44
p values*
Gender (males/females)19/3327/3617/270.69
Age/years (mean (SD))43.5 (14.5)52.6 (19)46.5 (16)0.11
Duration of onset (d) 45.60.19
Comorbidities n (%)No Comorbidity51400.18
 Asthma 8 (13%)9 (20%)0.25
 Chronic lung disease 7 (11%)9 (20%)0.12
 Cancer/ on chemotherapy 5 (7.9%)2 (4.5%)0.57
 Ischemic heart disease 12 (19%)6 (14%)0.45
 Hypertension 11 (17%)5 (11%)0.31
 Diabetes 8 (13%)9 (20%)0.25
Cell counts
 Total leukocytes 8.1 × 1000/mm39.6 × 1000/mm30.76
 Neutrophils 7.0 × 1000/mm37.4 × 1000/mm30.76
Respiratory support
 Invasive mechanical ventilation 0 (0%)42 (95%)< 0.0001
 Non-invasive support (CPAP) 0 (0%)2 (5%)< 0.0001
Outcomes
 HospitalizationNA45 (71%)44 (100%)< 0.0001
 Admission to ICUNA7 (11%)44 (100%)< 0.0001
 Length of hospital stayNA1.4 days26 days< 0.0001
 DeathNA0 (0%)9 (20%)< 0.0001
  1. * p values are calculated by comparing moderate and severe groups using Mann-Whitney test for continuous variables or Chi-square test for categorical variables. ICU denotes intensive care unit. NA denotes not applicable