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Table 1 Demographics and clinical characteristics of patients

From: Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection

 

Healthy Controls

n = 52

Moderate

n = 63

Severe

n = 44

p values*

Gender (males/females)

19/33

27/36

17/27

0.69

Age/years (mean (SD))

43.5 (14.5)

52.6 (19)

46.5 (16)

0.11

Duration of onset (d)

 

4

5.6

0.19

Comorbidities n (%)

No Comorbidity

51

40

0.18

 Asthma

 

8 (13%)

9 (20%)

0.25

 Chronic lung disease

 

7 (11%)

9 (20%)

0.12

 Cancer/ on chemotherapy

 

5 (7.9%)

2 (4.5%)

0.57

 Ischemic heart disease

 

12 (19%)

6 (14%)

0.45

 Hypertension

 

11 (17%)

5 (11%)

0.31

 Diabetes

 

8 (13%)

9 (20%)

0.25

Cell counts

 Total leukocytes

 

8.1 × 1000/mm3

9.6 × 1000/mm3

0.76

 Neutrophils

 

7.0 × 1000/mm3

7.4 × 1000/mm3

0.76

Respiratory support

 Invasive mechanical ventilation

 

0 (0%)

42 (95%)

< 0.0001

 Non-invasive support (CPAP)

 

0 (0%)

2 (5%)

< 0.0001

Outcomes

 Hospitalization

NA

45 (71%)

44 (100%)

< 0.0001

 Admission to ICU

NA

7 (11%)

44 (100%)

< 0.0001

 Length of hospital stay

NA

1.4 days

26 days

< 0.0001

 Death

NA

0 (0%)

9 (20%)

< 0.0001

  1. * p values are calculated by comparing moderate and severe groups using Mann-Whitney test for continuous variables or Chi-square test for categorical variables. ICU denotes intensive care unit. NA denotes not applicable