Dense module searching for gene networks associated with multiple sclerosis

BMC Medical Genomics

Table 2 MS FDA drug target genes within top modules

Drug name	Commercial product name	Target gene	Occurrence in top modules	GeneMSA gene-level p-value	IMSGC gene-level p-value
Fingolimod	Gilenya	HDAC1	Central in top module of GeneMSA, present in 75/75 top 1 % GeneMSA modules	0.263	0.249
Ocrelizumab	Ocrevus	IL2RA	Present in top modules of IMSGC GWAS and top module of dual evaluation, present in 76/76 top 1 % IMSGC modules	0.212	4.37 × 10⁻⁹
Dimethyl fumarate^a	Tecfidera	KEAP1	Present in 1/76 IMSGC top one present modules	0.172	2.22 × 10⁻⁶
Dimethyl fumarate^a	Tecfidera	RELA	Present in 3/75 top 1 % GeneMSA modules and 7/76 IMSGC top 1 % modules	0.084	1.84 × 10⁻⁴

^aDimethyl fumarate has two target genes from module gene list (KEAP1 and RELA)

ISSN: 1755-8794