Fig. 2

Consistent association signals identified by dmGWAS. (A) The subnetwork of all significant modules in two populations visualized by Cytoscape showing the consistent signals. Each circle represents a gene. For the genes with p-value ≥0.05 (insignificant), the color of the circle is set to white. For genes with p-value < 0.05, the area and color of the circle is proportional to gene’s weight. The stronger the color (red) is, the smaller the p-value is, and the stronger weight the gene is assigned. (B) A Venn diagram shows the overlap of genes from three sources. The yellow circle represents the 87 genes with consistent signals. The blue circle represents 194 human CL/P associated genes in the CleftGeneDB database. The green circle represents the 267 human genes homologous to mouse mutation genes in the CleftGeneDB database