Table 1 Pathways enriched in the dmGWAS module genes (discovery: European dataset, evaluation: Asian dataset)
Pathway ID | Description | Pathway size* | # informative genes$ | Adjusted p-value# |
|---|---|---|---|---|
GO Biological Process | ||||
 GO:0035690 | Cellular response to drug | 349 | 12 | 7.2 × 10−4 |
 GO:0051098 | Regulation of binding | 367 | 11 | 9.8 × 10− 3 |
 GO:0048545 | Response to steroid hormone | 388 | 11 | 0.017 |
 GO:0038093 | Fc receptor signaling pathway | 127 | 7 | 0.017 |
 GO:0045104 | Intermediate filament cytoskeleton organization | 48 | 5 | 0.022 |
 GO:0045103 | Intermediate filament-based process | 49 | 5 | 0.024 |
KEGG pathway | ||||
 hsa05210 | Colorectal cancer | 86 | 7 | 1.7 × 10−3 |
 hsa05165 | Human papillomavirus infection | 339 | 12 | 4.2 × 10−3 |
 hsa05170 | Human immunodeficiency virus 1 infection | 212 | 9 | 0.014 |
 hsa05014 | Amyotrophic lateral sclerosis (ALS) | 51 | 5 | 0.016 |
 hsa04360 | Axon guidance | 175 | 8 | 0.024 |
 hsa04666 | Fc gamma R-mediated phagocytosis | 91 | 6 | 0.027 |