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Table 1 Pathways enriched in the dmGWAS module genes (discovery: European dataset, evaluation: Asian dataset)

From: An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate

Pathway IDDescriptionPathway size*# informative genes$Adjusted p-value#
GO Biological Process
 GO:0035690Cellular response to drug349127.2 × 10−4
 GO:0051098Regulation of binding367119.8 × 10− 3
 GO:0048545Response to steroid hormone388110.017
 GO:0038093Fc receptor signaling pathway12770.017
 GO:0045104Intermediate filament cytoskeleton organization4850.022
 GO:0045103Intermediate filament-based process4950.024
KEGG pathway
 hsa05210Colorectal cancer8671.7 × 10−3
 hsa05165Human papillomavirus infection339124.2 × 10−3
 hsa05170Human immunodeficiency virus 1 infection21290.014
 hsa05014Amyotrophic lateral sclerosis (ALS)5150.016
 hsa04360Axon guidance17580.024
 hsa04666Fc gamma R-mediated phagocytosis9160.027
  1. *Pathway size: the total number of genes in the GO term or KEGG pathway
  2. $The observed number of genes from the module gene list
  3. #Bonferroni method was used to adjust p-value