Workflow of this study (a) Constructing an integrated tissue-specific PDAC network with weighted nodes and weighted edges using tissue PDAC expression profile, normal PDAC expression profile and PPI network data. b Constructing an integrated cell-line-specific PDAC network with weighted nodes and weighted edges using cell-line PDAC expression profile, CRISPR data and PPI network data. c Spectral clustering for integrated tissue-specific PDAC network. d Aligning clustering results on integrated cell-line-specific PDAC network and ranking targets with a scoring scheme (TI score). e Validation on top ranked targets.