Table 3 Statistics of top-ranked drug targets. Column 2: Ranks by SCNrank Column. 3: cancer drug target information. Column 4: average expression values in tumor tissue samples. Column 5: average expression values in normal tissue samples. Column 6: log2 fold change of expression differences between tumor group and tissue group. Column 7: T value from T-test between tumor and normal group. Column 8: P-value from T-test between tumor and normal group. Column 9: gene essentiality value (cell survival rate at T3 versus at T0). Positive values and negative values indicate an enhanced and reduced cell survival rate respectively in vitro
Name | RANK | Cancer drug target (Y/N) | Tumor gene expression (Log2 average) | Normal gene expression (Log2 average) | T_v_N Log2 FC | T-value | p-value | Gene essentiality in CRISPR |
|---|---|---|---|---|---|---|---|---|
PGK1 | 1 | N | 10.18 | 9.28 | 0.90 | 8.03 | < 0.01 | −1.84 |
POLE2 | 1 | Y | 5.87 | 4.83 | 1.04 | 5.31 | < 0.01 | −1.31 |
HMMR | 2 | N | 6.83 | 5.06 | 1.77 | 4.31 | < 0.01 | −0.96 |
VDAC1 | 4 | N | 9.53 | 8.83 | 0.70 | 6.30 | < 0.01 | −1.85 |
PPP2CA | 5 | N | 8.61 | 8.40 | 0.21 | 3.98 | < 0.01 | −1.94 |
DARS2 | 6 | N | 5.63 | 5.16 | 0.47 | 3.02 | < 0.01 | −0.54 |
TK1 | 7 | N | 6.56 | 5.95 | 0.61 | 3.37 | < 0.01 | −0.42 |
VARS | 8 | N | 5.52 | 5.14 | 0.38 | 3.01 | < 0.01 | −2.13 |
DHFR | 9 | Y | 7.09 | 6.45 | 0.64 | 3.75 | < 0.01 | −1.06 |
MMP14 | 10 | N | 7.40 | 6.51 | 0.89 | 4.37 | < 0.01 | −0.21 |
ERBB2 | 13 | Y | 6.65 | 5.58 | 1.07 | 3.23 | 0.01 | −0.20 |
MTOR | 32 | Y | 5.45 | 5.04 | 0.44 | 3.74 | < 0.01 | −1.24 |