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Table 4 Currently available drugs and drug targets for pancreatic cancer comparing associated target ranks from SCNrank algorithm

From: SCNrank: spectral clustering for network-based ranking to reveal potential drug targets and its application in pancreatic ductal adenocarcinoma

TargetsDrugTargets and their ranks
tyrosine kinase
 EGFRErlotinib+GemcitabineNA
 HER2TrastuzumabERBB2 (14)
 MAPKtrametinibMAP2K1 (233)
 MTOReverolimusMTOR (32)
 IGF-IRGanitumabIGF2R (87)
 JAKRuxolitinibNA
Angiogenesis
 VEGFBevacizumabPGK1 (1)
Others
 KRASGemcitabine+nab-paclitaxelNA
 DNA repairNiraparibNA
 Tumor VaccineGVAXNA