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Table 1 Summary of the Most Significant Genes in the GAIN Schizophrenia Data Analysis

From: Adaptive Fisher method detects dense and sparse signals in association analysis of SNV sets

GenewAFwAF daSPUSKATSKAT-ORelated DiseaseFunction
FAM69A1.20 ×10−54.00 ×10−51.70 ×10−56.31 ×10−66.41 ×10−6SCZ [33]Protein binding.
      MS [39] 
      Parkinson’s Disease [29] 
NUDT126.00 ×10−55.99 ×10−34.80 ×10−54.29 ×10−36.58 ×10−3Depressive Symptoms [43]Regulates the concentrations of individual
       nucleotides and of nucleotide ratios.
RPL56.00 ×10−59.00 ×10−51.00 ×10−43.57 ×10−52.76 ×10−5MS [39]Ribosomal protein, binds 5s RNA.
HPGDS8.00 ×10−56.00 ×10−41.50 ×10−45.16 ×10−57.89 ×10−5SCZ [34]PGH2 to PGD2 conversion enzyme.
SMARCAD11.00 ×10−41.30 ×10−41.10 ×10−46.06 ×10−51.53 ×10−4 Heterochromatin organization restoration
       epigenetic pattern propagation.
GTF2A11.20 ×10−41.00 ×10−31.70 ×10−49.90 ×10−59.98 ×10−5BD [35]Transcriptional activation.
NRN1L1.20 ×10−43.50 ×10−46.00 ×10−42.04 ×10−42.63 ×10−4Psychiatric Diseases[44]Neurite growth, neuronal survival.
CERCAM1.40 ×10−46.00 ×10−41.30 ×10−41.72 ×10−11.80 ×10−1 Probable cell adhesion protein.
SLC35A51.80 ×10−45.99 ×10−32.30 ×10−34.16 ×10−43.32 ×10−4Autistic Disorder[30]Nucleoside-sugar transporter.
STRA132.00 ×10−49.00 ×10−59.00 ×10−59.81 ×10−51.07 ×10−4SCZ [46]Mitotic progression and chromosome segregation.
ESRP22.90 ×10−42.60 ×10−44.30 ×10−41.85 ×10−41.97 ×10−4 An epithelial cell-type-specific splicing regulator.
LCAT6.00 ×10−46.00 ×10−43.10 ×10−49.80 ×10−41.08 ×10−3 Enzyme in the extracellular metabolism.
KIAA1024L1.00 ×10−36.00 ×10−41.00 ×10−38.76 ×10−46.66 ×10−4