a Box plot of log2 transformed tumor mutation burden (TMB) values from all available TCGA (The Cancer Genome Atlas) patients with respect to each cancer type, ordered according to Fig. 2. Texts and diamond symbols in red color indicated the mean values. b Mean TMB versus averaged concordance index results across 12 cancer types with three survival prognosis models. Pearson ρ = − 0.45 (p-value = 5.79E-03). Individual model correlations are range from −0.46 to −0.44, described in Additional file 1: Table S4. Other results of TMB statistics versus concordance index were shown in Additional file 1: Figure S2 – Figure S6.