Table 1 75 genes involved in AD enriched pathways
Pathway | Genes | Total |
|---|---|---|
Immune response-Alternative complement pathway | C3, CD46, CD55, CD59, CLU, CR1, ITGAM, ITGAX | 8 |
Development-Neurotrophin family signaling | MAPK3, BAX, BRAF, GAB1, GRB2, HRAS, JUN, MAGED1, MAP2K1, MAP2K2, MAP3K1, MAPK1,MAPK8, PIK3R1, PIP5K1A, PTPN11, RAC1, RAF1, RAP1A, RAPGEF1, SHC1, SORT1, SOS1, TP53,AK1 | 25 |
Neurophysiological process-NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons | AKT1, BRAF, CALM1, CREB1, EIF4E, GRB2, HRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, PIK3R1, PRKACA, RAP1A, RAPGEF3, RPS6KA1, RPS6KB1, SHC1, XYLT2 | 20 |
Cell adhesion-Ephrin signaling | ADAM10, CDC42, EPHA1, EPHB1, FYN, GRB10, HRAS, KALRN, MAP3K7, MAP4K4, MAPK8, NCK1, NCK2, PAK1, PXN, RAC1, RAF1, RAP1A, RASA1, RHOA, SLA, SLC10A3, SRC, GRB2 | 24 |
Neurophysiological process-nNOS signaling in neuronal synapses | CALM1, CALM2, CALM3, DLG4, GRIN2C, GRINA, PPP3CA PPP3CB, PPP3CC, PPP3R1, PRKCB, PRKCD, PRKCH, PRKCI, PRKD3 | 15 |