Fig. 7

Schematic representation of STAiR18’s role in INA-6 cells. [1] STAT3 induces STAiR18 expression. [2] STAiR18 interacts with STAT3 primary RNA within a SINE element. [3] Additionally, STAiR18 is involved in maintaining H3K36-trimethylation of the STAT3 locus, probably via SETD2. [4] This results in a positive feedback, yielding elevated STAT3 levels. Both STAT3 and STAiR18 ensure survival of multiple myeloma cells. [5] STAT3 triggers survival in part via miR21 [6] and Mcl-1 [5]. [6] However, the mechanism of STAiR18-mediated myeloma cell survival remains to be defined