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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain

Fig. 1

Active epigenetic marks in metastatic breast cancer cells. a Upset plots of shared and unique H3K4me3, H3K27ac or ATAC peaks for the indicated cell sub-populations. b Heatmaps depicting significantly differential (p < 0.05) H3K4me3 (left), H3K27ac (center), and ATAC (right) peaks in the comparison between BrM2 and Par or LM2 and Par. For each mark, genomic regions were ranked based on the signal in Par peaks. P values were calculated using DESeq2 and adjusted with the Benjamini-Hochberg (BH) method. c Correlation between log2 fold change of each ATAC peak and the log2 fold change of its overlapping H3K4me3 (left) and H3K27ac (right) peak. Log2 fold change is based on the comparison between all metastatic sub-populations and Par cells. Correlation estimate calculated using the Pearson correlation test

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BMC Medical Genomics

ISSN: 1755-8794

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