Fig. 1

The concept of dosage-sensitive genes and their definitions according to a previous study [17] and our pilot result in S6 Fig. (a) Copy number alterations in dosage-sensitive genes are harmful, but (b) copy number alterations in dosage-insensitive genes are not harmful. (c) According to a previous report [17], all genes can be classified into four groups: ohnologs with small-scale duplications (SSD); ohnologs without SSD; non-ohnologous duplicates; and singletons