Skip to main content

Table 1 Odds tables and ideal HLO-matrices for five interaction models

From: Modified entropy-based procedure detects gene-gene-interactions in unconventional genetic models

 OddsHLO
Multiplicative modelbbbBBBbbbBBB
aaαααHLL
aAαα(1+θ)α(1+θ)2LHH
AAαα(1+θ)2α(1+θ)4LHH
Epistasis modelbbbBBB 
aaαα(1+θ)α(1+θ)LHH
aAα(1+θ)ααHLL
AAα(1+θ)ααHLL
Two allele interaction-modelbbbBBBbbbBBB
aaααα(1+θ)LLH
aAαα(1+θ)αLHL
AAα(1+θ)ααHLL
XOR modelbbbBBBbbbBBB
aaαα(1+θ)αLHL
aAα(1+θ)αα(1+θ)HLH
AAαα(1+θ)αLHL
No margin-model with MAF=0.25bbbBBBbbbBBB
aa0.030.100.08LHH
aA0.090.010.04HLL
AA0.100.010.00HLO
  1. α, prevalence parameter, and θ, multiplicative interaction parameter. High (H), low (L), and undetermined (O) risk genotype combinations in the interaction models