Modified entropy-based procedure detects gene-gene-interactions in unconventional genetic models

BMC Medical Genomics

Table 1 Odds tables and ideal HLO-matrices for five interaction models

	Odds			HLO
Multiplicative model	bb	bB	BB	bb	bB	BB
aa	α	α	α	H	L	L
aA	α	α(1+θ)	α(1+θ)²	L	H	H
AA	α	α(1+θ)²	α(1+θ)⁴	L	H	H
Epistasis model	bb	bB	BB
aa	α	α(1+θ)	α(1+θ)	L	H	H
aA	α(1+θ)	α	α	H	L	L
AA	α(1+θ)	α	α	H	L	L
Two allele interaction-model	bb	bB	BB	bb	bB	BB
aa	α	α	α(1+θ)	L	L	H
aA	α	α(1+θ)	α	L	H	L
AA	α(1+θ)	α	α	H	L	L
XOR model	bb	bB	BB	bb	bB	BB
aa	α	α(1+θ)	α	L	H	L
aA	α(1+θ)	α	α(1+θ)	H	L	H
AA	α	α(1+θ)	α	L	H	L
No margin-model with MAF=0.25	bb	bB	BB	bb	bB	BB
aa	0.03	0.10	0.08	L	H	H
aA	0.09	0.01	0.04	H	L	L
AA	0.10	0.01	0.00	H	L	O

α, prevalence parameter, and θ, multiplicative interaction parameter. High (H), low (L), and undetermined (O) risk genotype combinations in the interaction models

ISSN: 1755-8794