Fig. 4

The schemes around the breakpoints of two different types of TCF3-HLF fusion transcripts are depicted. Two breakpoints clustering in two TCF3 intronic regions are distinguished. At the transcript level, type I translocation results in joining TCF3 exon 16 to HLF exon 4. Moreover, intronic sequences, new splice sites and inserted non-template sequences are attached to the HLF gene (purple shadowed line). Implications resulting from the insertion of certain sequences have not yet been studied. Type II translocation occurs downstream of TCF3 exon 15. In this case, TCF3 exon 16 is not part of the fusion transcript. Boxes correspond to exonic regions of the TCF3 gene (green) and the HLF gene (red). Lines correspond to intronic regions of the TCF3 gene (green) and the HLF gene (red). Additional upstream and downstream exons of the TCF3 and HLF gene are not graphically represented (broken coloured lines). Lightning bolts represent intronic breakpoints