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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

Fig. 2

Differential expression of circCAMSAP1, circCIRBP, circRPH3AL and circZKSCAN1 in diabetic islets. Expression levels of circular and linear transcripts of the top 5 most abundant circRNAs in human islets are given here in relation to T2D status. Islets from non-diabetic individuals are given in grey (n = 50), those from individuals with T2D are given in black (n = 20). Relative expression of each linear or circular RNA is given on the Y axis, and was quantified relative to the geometric mean across all samples, since endogenous control genes alone did not provide a stable baseline. Statistical significance in difference of expression between islets from donors with or without T2D is indicated by stars. * = < 0.05, ** = < 0.005, *** = < 0.001

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