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Table 1 Sample and donor characteristics for human islet samples used in this work

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

A.

 

Control (n = 50)

T2D (n = 20)

p-value

Mean

SD

Mean

SD

 

Age

40.66

14.25

53.55

9.22

< 0.001

BMI

28.30

6.83

33.05

10.31

0.027

SI

2.45

1.26

–

–

–

HbA1c

5.44

0.36

–

–

–

Purity

89.28

6.00

80.38

14.92

< 0.001

Viability

93.53

4.80

89.73

4.54

0.003

Sex

F (40%);

M (60%)

F (45%)

M (55%)

0.706

Ethnicity

white (74%)

other (26%)

white (45%)

other (55%)

0.348

B.

 

Major allele homozygotes

Heterozygotes and minor allele homozygotes

p-value

Mean

SD

Mean

SD

 

rs6819243 (CTBP1)

 Age

40.19

14.12

42.38

11.78

0.620

 BMI

27.85

5.34

27.16

7.03

0.715

 Purity

89.26

5.86

90.00

3.54

0.671

 Viability

93.33

5.68

94.12

2.38

0.633

 Sex

F (53%)

M (47%)

F (38%)

M (62%)

0.595

 Ethnicity

white (83%)

other (17%)

white (31%)

other (69%)

0.020

rs10758593 (GLIS3)

 Age

41.08

15.04

40.88

12.25

0.966

 BMI

26.27

4.14

29.07

5.80

0.130

 Purity

89.46

4.96

88.50

6.26

0.633

 Viability

94.81

3.09

92.33

5.37

0.133

 Sex

F (39%)

M (62%)

F (42%)

M (58%)

0.269

 Ethnicity

white (69%)

other (31%)

white (73%)

other (27%)

0.916

rs7177055 (HMG20A)

 Age

39.97

13.95

43.69

12.35

0.371

 BMI

27.83

5.63

29.87

9.46

0.355

 Purity

89.13

5.18

89.13

6.18

0.998

 Viability

93.37

4.03

93.34

6.70

0.986

 Sex

F (47%)

M (53%)

F (38%)

M (63%)

0.547

 Ethnicity

white (72%)

other (28%)

white (75%)

other (25%)

0.697

rs1111875 (IDE)

 Age

48.58

9.95

33.43

12.20

< 0.001

 BMI

30.05

8.52

26.50

4.80

0.088

 Purity

88.61

4.91

90.57

4.73

0.175

 Viability

94.57

3.30

93.57

4.20

0.374

 Sex

F (58%)

M (42%)

F (30%)

M (70%)

0.056

 Ethnicity

white (67%)

other (33%)

white (74%)

other (26%)

0.733

rs12427353 (SPPL3)

 Age

39.68

14.15

46.80

9.02

0.137

 BMI

29.03

7.32

25.03

4.00

0.104

 Purity

89.98

5.22

87.78

5.65

0.267

 Viability

93.48

5.28

94.33

3.50

0.645

 Sex

F (40%)

M (60%)

F (70%)

M (30%)

0.092

 Ethnicity

white (68%)

other (33%)

white (80%)

other (20%)

0.949

rs10203174 (THADA)

 Age

42.18

13.62

43.36

13.38

0.802

 BMI

29.07

7.54

25.54

5.13

0.155

 Purity

89.64

4.50

89.09

6.25

0.754

 Viability

93.85

4.25

94.64

2.46

0.565

 Sex

F (47%)

M (53%)

F (36%)

M (64%)

0.546

 Ethnicity

white (74%)

other (26%)

white (55%)

other (45%)

0.920

  1. A. Characteristics of human islet preparations from donors with (n = 20) and without (n = 50) T2D. B. Characteristics of human islet preparations from control donors used for GWAS genotype analysis (n = 53). SD = standard deviation. Islet sets for parts A and B are only partly overlapping; non-diabetic samples used for assessment of effects of diabetes status were selected from the larger pool to allow for matching of islet donors with and without diabetes. Differences in parameters between islet groups was determined by t-test. B. Characteristics of human peripheral blood donors with (n = 20) and without (n = 50) T2D
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BMC Medical Genomics

ISSN: 1755-8794

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