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Table 1 Sample and donor characteristics for human islet samples used in this work

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

A.
 Control (n = 50)T2D (n = 20)p-value
MeanSDMeanSD 
Age40.6614.2553.559.22< 0.001
BMI28.306.8333.0510.310.027
SI2.451.26
HbA1c5.440.36
Purity89.286.0080.3814.92< 0.001
Viability93.534.8089.734.540.003
SexF (40%);M (60%)F (45%)M (55%)0.706
Ethnicitywhite (74%)other (26%)white (45%)other (55%)0.348
B.
 Major allele homozygotesHeterozygotes and minor allele homozygotesp-value
MeanSDMeanSD 
rs6819243 (CTBP1)
Age40.1914.1242.3811.780.620
BMI27.855.3427.167.030.715
Purity89.265.8690.003.540.671
Viability93.335.6894.122.380.633
SexF (53%)M (47%)F (38%)M (62%)0.595
Ethnicitywhite (83%)other (17%)white (31%)other (69%)0.020
rs10758593 (GLIS3)
Age41.0815.0440.8812.250.966
BMI26.274.1429.075.800.130
Purity89.464.9688.506.260.633
Viability94.813.0992.335.370.133
SexF (39%)M (62%)F (42%)M (58%)0.269
Ethnicitywhite (69%)other (31%)white (73%)other (27%)0.916
rs7177055 (HMG20A)
Age39.9713.9543.6912.350.371
BMI27.835.6329.879.460.355
Purity89.135.1889.136.180.998
Viability93.374.0393.346.700.986
SexF (47%)M (53%)F (38%)M (63%)0.547
Ethnicitywhite (72%)other (28%)white (75%)other (25%)0.697
rs1111875 (IDE)
Age48.589.9533.4312.20< 0.001
BMI30.058.5226.504.800.088
Purity88.614.9190.574.730.175
Viability94.573.3093.574.200.374
SexF (58%)M (42%)F (30%)M (70%)0.056
Ethnicitywhite (67%)other (33%)white (74%)other (26%)0.733
rs12427353 (SPPL3)
Age39.6814.1546.809.020.137
BMI29.037.3225.034.000.104
Purity89.985.2287.785.650.267
Viability93.485.2894.333.500.645
SexF (40%)M (60%)F (70%)M (30%)0.092
Ethnicitywhite (68%)other (33%)white (80%)other (20%)0.949
rs10203174 (THADA)
Age42.1813.6243.3613.380.802
BMI29.077.5425.545.130.155
Purity89.644.5089.096.250.754
Viability93.854.2594.642.460.565
SexF (47%)M (53%)F (36%)M (64%)0.546
Ethnicitywhite (74%)other (26%)white (55%)other (45%)0.920
  1. A. Characteristics of human islet preparations from donors with (n = 20) and without (n = 50) T2D. B. Characteristics of human islet preparations from control donors used for GWAS genotype analysis (n = 53). SD = standard deviation. Islet sets for parts A and B are only partly overlapping; non-diabetic samples used for assessment of effects of diabetes status were selected from the larger pool to allow for matching of islet donors with and without diabetes. Differences in parameters between islet groups was determined by t-test. B. Characteristics of human peripheral blood donors with (n = 20) and without (n = 50) T2D