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Table 4 Association of expression of circRNAs mapping to T2D-GWAS loci and their parental transcripts with genotype in primary non-diabetic islets

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

Transcript

 

GG

Gg and gg

p-value

Mean

SD

Mean

SD

rs6819243

 CTBP1

0.781

−0.11

0.32

−0.04

0.34

 CircCTBP1_1

0.274

−0.03

0.65

0.09

0.37

 CircCTBP1_2

0.293

0.00

0.85

0.11

0.85

rs10758593

 GLIS3

0.139

−0.19

0.37

0.02

0.36

 CircGLIS3

0.535

0.03

0.37

0.04

0.41

rs7177055

 HMG20A

0.502

−0.03

0.38

0.09

0.37

 CircHMG20A

0.952

0.03

0.36

0.03

0.38

rs1111875

 IDE

0.578

−0.66

0.39

−0.46

0.35

 CircIDE1

0.953

−0.02

0.40

0.04

0.45

 CircIDE2

0.937

−0.02

0.23

0.02

0.36

rs12427353

 SPPL3

0.808

−0.01

0.48

0.05

0.43

 CircSPPL3_1

0.677

−0.02

0.45

0.06

0.34

 CircSPPL3_2

0.595

0.01

0.48

0.21

0.48

rs10203174

 THADA

0.369

−0.02

0.61

0.22

0.50

 CircTHADA1

0.672

0.05

0.40

0.10

0.42

 CircTHADA2

0.282

−0.01

0.86

− 0.33

0.96

 CircTHADA3

0.133

0.11

0.32

0.16

0.45

 CircTHADA4

0.319

0.06

0.39

−0.24

0.46

 CircTHADA5

0.651

0.14

0.59

0.27

0.40

  1. The association between circRNA/linear transcript expression and genotype for circRNAs located to GWAS loci for T2D are given. Heterozygous samples and minor allele homozygotes are combined into one category. SD = standard deviation. Genotypes: GG = most common allele observed. Gg = heterozygotes, gg = minor allele heterozygotes
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BMC Medical Genomics

ISSN: 1755-8794

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