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Table 4 Association of expression of circRNAs mapping to T2D-GWAS loci and their parental transcripts with genotype in primary non-diabetic islets

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

Transcript GGGg and gg
p-valueMeanSDMeanSD
rs6819243
CTBP10.781−0.110.32−0.040.34
CircCTBP1_10.274−0.030.650.090.37
CircCTBP1_20.2930.000.850.110.85
rs10758593
GLIS30.139−0.190.370.020.36
CircGLIS30.5350.030.370.040.41
rs7177055
HMG20A0.502−0.030.380.090.37
CircHMG20A0.9520.030.360.030.38
rs1111875
IDE0.578−0.660.39−0.460.35
CircIDE10.953−0.020.400.040.45
CircIDE20.937−0.020.230.020.36
rs12427353
SPPL30.808−0.010.480.050.43
CircSPPL3_10.677−0.020.450.060.34
CircSPPL3_20.5950.010.480.210.48
rs10203174
THADA0.369−0.020.610.220.50
CircTHADA10.6720.050.400.100.42
CircTHADA20.282−0.010.86− 0.330.96
CircTHADA30.1330.110.320.160.45
CircTHADA40.3190.060.39−0.240.46
CircTHADA50.6510.140.590.270.40
  1. The association between circRNA/linear transcript expression and genotype for circRNAs located to GWAS loci for T2D are given. Heterozygous samples and minor allele homozygotes are combined into one category. SD = standard deviation. Genotypes: GG = most common allele observed. Gg = heterozygotes, gg = minor allele heterozygotes