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Table 5 Expression of most abundantly expressed circRNAs and their parental transcripts in EndoC-βH1 cells treated with diabetes-related stresses

From: Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

TranscriptTreatmentp-valueMedian (IQR)
CAMSAP1Control 1.11 (0.95–1.39)
2.5 mM glucose0.3131.03 (0.92–1.05)
25 mM glucose0.4440.96 (0.95–1.17)
Control 0.92 (0.89–1.06)
1% O20.6940.97 (0.73–1.04)
3% O20.3470.88 (0.63–0.99)
Control 1.05 (0.95–1.08)
Palmitic acid0.0620.89 (0.77–0.94)
Control 0.93 (0.25–1.21)
Cytokines0.6350.95 (0.90–0.99)
CircCAMSAP1Control 0.84 (0.79–1.11)
2.5 mM glucose0.7621.02 (0.75–1.12)
25 mM glucose0.6810.92 (0.78–1.29)
Control 0.98 (0.92–1.14)
1% O20.1360.89 (0.76–0.93)
3% O20.2920.83 (0.63–1.07)
Control 1.04 (1.02–1.23)
Palmitic acid0.0900.82 (0.65–1.00)
Control 0.77 (0.27–1.14)
Cytokines0.5550.99 (0.69–1.02)
CIRBPControl 1.06 (0.83–1.08)
2.5 mM glucose0.0801.38 (1.10–1.53)
25 mM glucose0.0771.30 (1.14–1.56)
Control 1.01 (0.99–1.09)
1% O20.1460.79 (0.39–0.97)
3% O20.1290.84 (0.74–1.02)
Control 0.88 (0.65–1.09)
Palmitic acid0.9070.91 (0.64–1.15)
Control 0.90 (0.03–1.34)
Cytokines0.5930.95 (0.93–1.06)
CircCIRBPControl 0.77 (0.61–1.42)
2.5 mM glucose0.8440.86 (0.32–1.37)
25 mM glucose0.6520.77 (0.72–0.94)
Control 1.10 (1.00–1.23)
1% O20.9550.86 (0.56–2.00)
3% O20.7260.89 (0.68–1.48)
Control 0.75 (0.72–1.04)
Palmitic acid0.0211.69 (1.30–1.98)
Control 1.17 (1.00–1.33)
Cytokines0.1800.73 (0.69–1.06)
RPH3ALControl 1.05 (0.93–1.06)
2.5 mM glucose0.5030.99 (0.75–1.07)
25 mM glucose0.4410.93 (0.80–1.08)
Control 1.09 (1.06–1.37)
1% O20.3571.55 (1.04–1.56)
3% O20.2051.32 (1.28–1.81)
Control 0.95 (0.87–0.99)
Palmitic acid0.1020.84 (0.70–0.87)
Control 0.98 (0.02–1.01)
Cytokines0.3541.02 (0.91–1.12)
CircRPH3ALControl 1.00 (0.45–1.00)
2.5 mM glucose0.9410.85 (0.58–0.97)
25 mM glucose0.8670.76 (0.73–0.86)
Control 1.09 (1.06–1.37)
1% O20.3571.55 (1.04–1.56)
3% O20.2051.32 (1.28–1.81)
Control 1.66 (1.32–1.85)
Palmitic acid0.0220.97 (0.95–1.11)
Control 0.68 (0.47–0.77)
Cytokines0.2950.97 (0.55–1.02)
RHOBTB3Control 1.24 (1.23–1.31)
2.5 mM glucose0.1881.11 (1.00–1.27)
25 mM glucose0.1171.20 (0.72–1.14)
Control 0.95 (0.69–1.06)
1% O20.9490.97 (0.77–0.98)
3% O20.3530.67 (0.65–0.93)
Control 0.80 (0.72–0.90)
Palmitic acid0.0031.18 (1.15–1.21)
Control 1.17 (0.29–1.35)
Cytokines0.1861.59 (1.22–1.72)
CircRHOBTB3Control 0.74 (0.73–1.00)
2.5 mM glucose0.8360.89 (0.65–1.02)
25 mM glucose0.3510.77 (0.57–0.78)
Control 1.04 (0.72–1.08)
1% O20.1820.78 (0.74–0.78)
3% O20.2880.79 (0.77–0.86)
Control 1.16 (0.99–1.27)
Palmitic acid0.3061.03 (0.83–1.13)
Control 1.01 (0.95–1.08)
Cytokines0.6280.97 (0.89–1.06)
ZKSCAN1Control 1.24 (1.18–1.33)
2.5 mM glucose0.6321.23 (1.05–1.87)
25 mM glucose0.9971.23 (1.16–1.36)
Control 0.93 (0.86–1.08)
1% O20.3881.06 (0.94–1.12)
3% O20.2180.72 (0.66–0.98)
Control 0.50 (0.39–0.55)
Palmitic acid0.0011.01 (0.94–1.12)
Control 1.29 (0.24–1.33)
Cytokines0.3781.30 (1.27–1.35)
CircZKSCAN1Control 0.86 (0.81–1.17)
2.5 mM glucose0.4900.91 (0.83–1.17)
25 mM glucose0.5050.88 (0.83–1.28)
Control 1.11 (0.99–1.42)
1% O20.0601.65 (1.41–1.79)
3% O20.6311.24 (1.02–1.57)
Control 1.01 (0.81–1.45)
Palmitic acid0.2520.83 (0.75–0.91)
Control 1.05 (0.10–1.13)
Cytokines0.2921.16 (1.13–1.18)
  1. We assessed the effect of diabetes-related cellular stresses (low/high glucose, elevated fatty acid, hypoxia and exposure to pro-inflammatory cytokines) on the expression of the 5 most abundant islet circRNAs in the Endo-βH1 human beta cell line. IQR = interquartile range. Results meeting the threshold for 4 test conditions are given in bold underlined type, those presenting nominal associations only are indicated in bold italic type