Fig. 3

ERα-related chromosomal rearrangements of the five 17q regions. a, b. Comparison of frequencies of chromosomal rearrangements between ATC-prone tumors (n = 15) and ATC-less tumors (n = 15). Circos plots of inter- (a) and intra- (b) chromosomal rearrangements related to two 17q regions and one negative control region on 14q. The plots of the rest 17q regions were displayed in Additional file 1: Figure S2. c. Frequencies of inter−/intra-chromosomal rearrangements in the five 17q regions by the hormone receptor status. d. Frequencies of inter−/intra-chromosomal rearrangements of each 17q regions against the 170 dense ERα binding sites of the whole genome. The dense ERα binding sites were ordered based on their genomic locations in each chromosome on the X-axis of the heat map (also see Additional file 2: Table S1). e. Examples of inter−/intra-chromosomal rearrangements against specific dense ERα binding site from two 17q regions (Region A and Region E pointed by black arrows). Locations of ERα binding sites from MCF-7, T47D, and MDA-MB-134 were displayed outside around the Circos plots