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Table 6 Analysis based on different genetic models

From: Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study

SNP number Gene Position Genetic models OR 95%CI P-value* Bonferroni correction
P-value
rs713729 PICK1 22: 38,059,462 Multiplicative 2.12 1.34–3.36 0.001 0.003
Dominant 2.08 1.21–3.57 0.007 0.020
Recessive 2.51 0.97–6.52 0.05 0.149
Co-dominant 2.71 1.04–7.06 0.02 0.061
rs2076369 PICK1 22: 38,067,645 Multiplicative 0.68 0.05–0.91 0.009 0.028
Dominant 0.51 0.34–0.76 0.0008 0.003
Recessive 0.92 0.51–1.67 0.806 -
Co-dominant 0.64 0.34–1.21 0.003 0.008
rs6265 BDNF 11: 27,658,369 Multiplicative 1.09 0.74–1.61 0.65 -
Dominant 1.05 0.68–1.63 0.81 -
Recessive 1.75 0.43–7.13 0.64 -
Co-dominant 1.76 0.43–7.18 0.89 -
  1. PICK1: Protein interacting with C-kinase-1; BDNF: Brain-derived neurotrophic factor; SNP: Single nucleotide polymorphism. OR: Odds ratio; CI: Confidence interval; P-values were obtained from Chi-square tests; *Significant of P-value < 0.05; The association between methamphetamine, risk factors and alleles/genotypes was evaluated by binary logistic regression, estimating ORs and also CIs. Note: Significant P-value in bold; Bonferroni corrected P-value is 0.016