Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study

Table 6 Analysis based on different genetic models

SNP number	Gene	Position	Genetic models	OR	95%CI	P_-value*	Bonferroni correction
SNP number	Gene	Position	Genetic models	OR	95%CI	P_-value*	P_-value
rs713729	PICK1	22: 38,059,462	Multiplicative	2.12	1.34–3.36	0.001	0.003
			Dominant	2.08	1.21–3.57	0.007	0.020
			Recessive	2.51	0.97–6.52	0.05	0.149
			Co-dominant	2.71	1.04–7.06	0.02	0.061
rs2076369	PICK1	22: 38,067,645	Multiplicative	0.68	0.05–0.91	0.009	0.028
			Dominant	0.51	0.34–0.76	0.0008	0.003
			Recessive	0.92	0.51–1.67	0.806	-
			Co-dominant	0.64	0.34–1.21	0.003	0.008
rs6265	BDNF	11: 27,658,369	Multiplicative	1.09	0.74–1.61	0.65	-
			Dominant	1.05	0.68–1.63	0.81	-
			Recessive	1.75	0.43–7.13	0.64	-
			Co-dominant	1.76	0.43–7.18	0.89	-

PICK1: Protein interacting with C-kinase-1; BDNF: Brain-derived neurotrophic factor; SNP: Single nucleotide polymorphism. OR: Odds ratio; CI: Confidence interval; P_-values were obtained from Chi-square tests; *Significant of P-_value < 0.05; The association between methamphetamine, risk factors and alleles/genotypes was evaluated by binary logistic regression, estimating ORs and also CIs. Note: Significant P_-value in bold; Bonferroni corrected P_-value is 0.016

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