Whole-exome sequencing in 168 Korean patients with inherited retinal degeneration

BMC Medical Genomics

Table 2 Comparison of exome capture products

	SureSelect Human All Exon v6		xGen Lockdown panel (n = 9^a)	P value^b	P value^c	P value^d
	150-bp paired-end reads (n = 9^a)	350-bp paired-end reads (n = 9^a)	xGen Lockdown panel (n = 9^a)
	Mean ± SD	Mean ± SD	Mean ± SD
Evenness (%)	75.3 ± 5.7	79.9 ± 0.4	76.6 ± 0.1	< 0.001	0.258	< 0.001
Depth (x)	61.3 ± 3.8	47.6 ± 0.5	56.3 ± 1.1	< 0.001	< 0.001	< 0.001
Duplication rate (%)	33.4 ± 2.4	17.5 ± 0.2	22.9 ± 0.4	< 0.001	< 0.001	< 0.001
≥ 20 × depth fraction (%)	87.9 ± 7.4	90.8 ± 0.6	91.3 ± 0.2	0.258	0.258	0.258
Sensitivity (%)	94.9 ± 4.0	97.8 ± 0.1	96.5 ± 0.2	< 0.001	0.258	< 0.001
Positive predictive value (%)	74.9 ± 0.7	73.8 ± 0.2	76.1 ± 0.2	< 0.001	< 0.001	< 0.001

SD standard deviation
^aThree sets of three identical samples
^bP value comparing SureSelect Human All Exon v6 150-bp paired-end reads with 350-bp paired-end reads
^cP value comparing SureSelect Human All Exon v6 150-bp paired-end reads with xGen Lockdown panel
^dP value comparing SureSelect Human All Exon v6 350-bp paired-end reads with xGen Lockdown panel

ISSN: 1755-8794