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Table 2 Comparison of exome capture products

From: Whole-exome sequencing in 168 Korean patients with inherited retinal degeneration

  SureSelect Human All Exon v6 xGen Lockdown panel (n = 9a) P valueb P valuec P valued
150-bp paired-end reads (n = 9a) 350-bp paired-end reads (n = 9a)
Mean ± SD Mean ± SD Mean ± SD
Evenness (%) 75.3 ± 5.7 79.9 ± 0.4 76.6 ± 0.1 < 0.001 0.258 < 0.001
Depth (x) 61.3 ± 3.8 47.6 ± 0.5 56.3 ± 1.1 < 0.001 < 0.001 < 0.001
Duplication rate (%) 33.4 ± 2.4 17.5 ± 0.2 22.9 ± 0.4 < 0.001 < 0.001 < 0.001
 ≥ 20 × depth fraction (%) 87.9 ± 7.4 90.8 ± 0.6 91.3 ± 0.2 0.258 0.258 0.258
Sensitivity (%) 94.9 ± 4.0 97.8 ± 0.1 96.5 ± 0.2 < 0.001 0.258 < 0.001
Positive predictive value (%) 74.9 ± 0.7 73.8 ± 0.2 76.1 ± 0.2 < 0.001 < 0.001 < 0.001
  1. SD standard deviation
  2. aThree sets of three identical samples
  3. bP value comparing SureSelect Human All Exon v6 150-bp paired-end reads with 350-bp paired-end reads
  4. cP value comparing SureSelect Human All Exon v6 150-bp paired-end reads with xGen Lockdown panel
  5. dP value comparing SureSelect Human All Exon v6 350-bp paired-end reads with xGen Lockdown panel