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Table 3 The Gene Ontology (GO) functional terms enriched for the differentially expressed mRNAs

From: Competing endogenous RNA network analysis explores the key lncRNAs, miRNAs, and mRNAs in type 1 diabetes

Category Term Count Genes Adjusted p value
BP GO:0006952 defense response 33 CXCL1, PRF1, KLRC3, TNF, PGLYRP1, CXCR1, CCL5, CCL4, SH2D1A, IFNG, CSF3R, MS4A2, LTF, SERPINA1, CRISP3, IL18RAP, RNASE3, CAMP, GNLY, IL1RN, CHST2, CD160, SAMHD1, SLAMF7, CD180, NCR3, PROK2, TNFAIP6, KLRG1, CCR3, LYST, ALOX5, F2R 5.01E-08
BP GO:0006955 immune response 29 HLA-DQB1, CXCL1, TNF, AQP9, PGLYRP1, CCL5, CCL4, CD96, SH2D1A, IFNG, CEACAM8, LTF, MS4A2, CRISP3, IL18RAP, GZMA, NCF4, IL1RN, EOMES, SAMHD1, SLAMF7, CD180, HLA-DQA1, CTSW, NCR3, CST7, ETS1, LYST, TGFBR3 1.11E-04
BP GO:0009611 response to wounding 24 CXCL1, TNF, IL18RAP, IL1RN, CHST2, CXCR1, CCL5, CCL4, CD180, NCR3, PROK2, TNFAIP6, KLRG1, DYSF, ADM, CCR3, MTPN, MS4A2, JAK2, SERPINA1, ID3, ALOX5, NRG1, F2R 3.46E-04
BP GO:0006954 inflammatory response 18 CXCL1, TNF, IL18RAP, IL1RN, CHST2, CXCR1, CCL5, CCL4, CD180, NCR3, TNFAIP6, PROK2, KLRG1, CCR3, MS4A2, SERPINA1, ALOX5, F2R 6.96E-04
BP GO:0006968 cellular defense response 8 PRF1, SH2D1A, KLRC3, KLRG1, CCR3, GNLY, CD160, CCL5 5.26E-03
BP GO:0008285 negative regulation of cell proliferation 17 CEBPA, COL18A1, CXCL1, TNF, PTPRM, ZBTB16, SKAP2, ADM, ETS1, IFNG, TGFBR3, JAK2, ADAMTS1, DLG5, IGFBP3, RUNX3, F2R 7.51E-03
BP GO:0009617 response to bacterium 12 TNF, RNASE3, ADM, LYST, CAMP, GNLY, IFNG, PGLYRP1, LTF, SERPINA1, CCL5, F2R 1.31E-02
BP GO:0002703 regulation of leukocyte mediated immunity 7 SH2D1A, TBX21, IFNG, MS4A2, CD226, LAG3, NCR3 2.83E-02
BP GO:0019835 cytolysis 5 GZMM, PRF1, GZMA, GZMB, GZMH 3.10E-02
BP GO:0051270 regulation of cell motion 11 COL18A1, PTPRM, ETS1, SMAD7, MMP9, RRAS2, TGFBR3, JAK2, ARAP3, IGFBP3, F2R 3.59E-02
BP GO:0031343 positive regulation of cell killing 5 SH2D1A, IFNG, CD226, LAG3, NCR3 3.87E-02
BP GO:0030099 myeloid cell differentiation 8 CEBPA, CDC42, TNF, MMP9, TGFBR3, JAK2, ZBTB16, FLVCR1 3.92E-02
BP GO:0042127 regulation of cell proliferation 24 CEBPA, COL18A1, CXCL1, NAMPT, TNF, PTPRM, ZBTB16, SKAP2, HHEX, IL12RB1, ADM, ETS1, HLX, IFNG, TGFBR3, JAK2, ADAMTS1, DLG5, NRG1, TCF3, IGFBP3, RUNX3, F2R, MATK 4.15E-02
BP GO:0002697 regulation of immune effector process 8 SH2D1A, TNF, TBX21, IFNG, MS4A2, CD226, LAG3, NCR3 4.63E-02
BP GO:0030334 regulation of cell migration 10 COL18A1, PTPRM, SMAD7, MMP9, RRAS2, TGFBR3, JAK2, ARAP3, IGFBP3, F2R 4.74E-02
BP GO:0031341 regulation of cell killing 5 SH2D1A, IFNG, CD226, LAG3, NCR3 4.89E-02
CC GO:0044459 plasma membrane part 48 HLA-DQB1, KCNJ15, TNF, AQP9, APH1A, FFAR2, CD247, KCNJ2, SIRPB1, CD96, CDC42, IL12RB1, DYSF, CEACAM8, CSF3R, MS4A2, CSF2RB, DLG5, KLRF1, NRG1, KLRD1, LAG3, CSF2RA, FLVCR1, IL2RB, PTPRM, STX3, CD3G, SMAD7, GZMA, NCF4, SYT11, PTPN4, CD160, ABCB1, GZMB, HLA-DQA1, NCR3, TNFRSF10C, NPC1, CCR3, RRAS2, TGFBR3, JAK2, RGS9, NKG7, CD226, F2R 2.72E-02
CC GO:0031226 intrinsic to plasma membrane 31 KCNJ15, TNF, AQP9, APH1A, FFAR2, KCNJ2, SIRPB1, CD96, IL12RB1, CEACAM8, CSF3R, MS4A2, CSF2RB, KLRF1, CSF2RA, FLVCR1, IL2RB, CD3G, PTPRM, SYT11, NCF4, CD160, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, TGFBR3, NKG7, CD226, F2R 2.90E-02
CC GO:0005887 integral to plasma membrane 30 KCNJ15, TNF, AQP9, APH1A, FFAR2, KCNJ2, SIRPB1, CD96, IL12RB1, CEACAM8, MS4A2, CSF2RB, CSF3R, KLRF1, CSF2RA, FLVCR1, IL2RB, CD3G, PTPRM, SYT11, NCF4, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, TGFBR3, NKG7, CD226, F2R 3.46E-02
CC GO:0005886 plasma membrane 72 KCNJ15, AQP9, CXCR1, SKAP2, LGR6, SIRPB1, CDC42, CD96, DYSF, CEACAM8, OSCAR, S1PR5, SMAGP, CSF2RB, MS4A2, CSF3R, DLG5, NRG1, KLRD1, CSF2RA, LAG3, FLVCR1, KLRB1, STX3, CD3G, PTPRM, GZMA, GPR171, NCF4, CD160, SIGLEC10, GZMB, BASP1, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, RRAS2, PTGDR, CD226, HLA-DQB1, ENPP5, PRF1, GPRC5D, TNF, APH1A, FFAR2, CD247, ZBTB16, KCNJ2, ACSL1, IL12RB1, COL6A3, KLRF1, IL2RB, SMAD7, SYT11, PTPN4, ABCB1, CD180, TIGIT, P2RY13, TGFBR3, JAK2, RGS9, ALOX5, ARAP3, NKG7, GCA, F2R, FEZ1 3.88E-02
  1. BP, biological process; CC, cellular component