Table 3 The Gene Ontology (GO) functional terms enriched for the differentially expressed mRNAs

BP

GO:0006952 defense response

33

CXCL1, PRF1, KLRC3, TNF, PGLYRP1, CXCR1, CCL5, CCL4, SH2D1A, IFNG, CSF3R, MS4A2, LTF, SERPINA1, CRISP3, IL18RAP, RNASE3, CAMP, GNLY, IL1RN, CHST2, CD160, SAMHD1, SLAMF7, CD180, NCR3, PROK2, TNFAIP6, KLRG1, CCR3, LYST, ALOX5, F2R

5.01E-08

BP

GO:0006955 immune response

29

HLA-DQB1, CXCL1, TNF, AQP9, PGLYRP1, CCL5, CCL4, CD96, SH2D1A, IFNG, CEACAM8, LTF, MS4A2, CRISP3, IL18RAP, GZMA, NCF4, IL1RN, EOMES, SAMHD1, SLAMF7, CD180, HLA-DQA1, CTSW, NCR3, CST7, ETS1, LYST, TGFBR3

1.11E-04

BP

GO:0009611 response to wounding

24

CXCL1, TNF, IL18RAP, IL1RN, CHST2, CXCR1, CCL5, CCL4, CD180, NCR3, PROK2, TNFAIP6, KLRG1, DYSF, ADM, CCR3, MTPN, MS4A2, JAK2, SERPINA1, ID3, ALOX5, NRG1, F2R

3.46E-04

BP

GO:0006954 inflammatory response

18

CXCL1, TNF, IL18RAP, IL1RN, CHST2, CXCR1, CCL5, CCL4, CD180, NCR3, TNFAIP6, PROK2, KLRG1, CCR3, MS4A2, SERPINA1, ALOX5, F2R

6.96E-04

BP

GO:0006968 cellular defense response

8

PRF1, SH2D1A, KLRC3, KLRG1, CCR3, GNLY, CD160, CCL5

5.26E-03

BP

GO:0008285 negative regulation of cell proliferation

17

CEBPA, COL18A1, CXCL1, TNF, PTPRM, ZBTB16, SKAP2, ADM, ETS1, IFNG, TGFBR3, JAK2, ADAMTS1, DLG5, IGFBP3, RUNX3, F2R

7.51E-03

BP

GO:0009617 response to bacterium

12

TNF, RNASE3, ADM, LYST, CAMP, GNLY, IFNG, PGLYRP1, LTF, SERPINA1, CCL5, F2R

1.31E-02

BP

GO:0002703 regulation of leukocyte mediated immunity

7

SH2D1A, TBX21, IFNG, MS4A2, CD226, LAG3, NCR3

2.83E-02

BP

GO:0019835 cytolysis

5

GZMM, PRF1, GZMA, GZMB, GZMH

3.10E-02

BP

GO:0051270 regulation of cell motion

11

COL18A1, PTPRM, ETS1, SMAD7, MMP9, RRAS2, TGFBR3, JAK2, ARAP3, IGFBP3, F2R

3.59E-02

BP

GO:0031343 positive regulation of cell killing

5

SH2D1A, IFNG, CD226, LAG3, NCR3

3.87E-02

BP

GO:0030099 myeloid cell differentiation

8

CEBPA, CDC42, TNF, MMP9, TGFBR3, JAK2, ZBTB16, FLVCR1

3.92E-02

BP

GO:0042127 regulation of cell proliferation

24

CEBPA, COL18A1, CXCL1, NAMPT, TNF, PTPRM, ZBTB16, SKAP2, HHEX, IL12RB1, ADM, ETS1, HLX, IFNG, TGFBR3, JAK2, ADAMTS1, DLG5, NRG1, TCF3, IGFBP3, RUNX3, F2R, MATK

4.15E-02

BP

GO:0002697 regulation of immune effector process

8

SH2D1A, TNF, TBX21, IFNG, MS4A2, CD226, LAG3, NCR3

4.63E-02

BP

GO:0030334 regulation of cell migration

10

COL18A1, PTPRM, SMAD7, MMP9, RRAS2, TGFBR3, JAK2, ARAP3, IGFBP3, F2R

4.74E-02

BP

GO:0031341 regulation of cell killing

5

SH2D1A, IFNG, CD226, LAG3, NCR3

4.89E-02

CC

GO:0044459 plasma membrane part

48

HLA-DQB1, KCNJ15, TNF, AQP9, APH1A, FFAR2, CD247, KCNJ2, SIRPB1, CD96, CDC42, IL12RB1, DYSF, CEACAM8, CSF3R, MS4A2, CSF2RB, DLG5, KLRF1, NRG1, KLRD1, LAG3, CSF2RA, FLVCR1, IL2RB, PTPRM, STX3, CD3G, SMAD7, GZMA, NCF4, SYT11, PTPN4, CD160, ABCB1, GZMB, HLA-DQA1, NCR3, TNFRSF10C, NPC1, CCR3, RRAS2, TGFBR3, JAK2, RGS9, NKG7, CD226, F2R

2.72E-02

CC

GO:0031226 intrinsic to plasma membrane

31

KCNJ15, TNF, AQP9, APH1A, FFAR2, KCNJ2, SIRPB1, CD96, IL12RB1, CEACAM8, CSF3R, MS4A2, CSF2RB, KLRF1, CSF2RA, FLVCR1, IL2RB, CD3G, PTPRM, SYT11, NCF4, CD160, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, TGFBR3, NKG7, CD226, F2R

2.90E-02

CC

GO:0005887 integral to plasma membrane

30

KCNJ15, TNF, AQP9, APH1A, FFAR2, KCNJ2, SIRPB1, CD96, IL12RB1, CEACAM8, MS4A2, CSF2RB, CSF3R, KLRF1, CSF2RA, FLVCR1, IL2RB, CD3G, PTPRM, SYT11, NCF4, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, TGFBR3, NKG7, CD226, F2R

3.46E-02

CC

GO:0005886 plasma membrane

72

KCNJ15, AQP9, CXCR1, SKAP2, LGR6, SIRPB1, CDC42, CD96, DYSF, CEACAM8, OSCAR, S1PR5, SMAGP, CSF2RB, MS4A2, CSF3R, DLG5, NRG1, KLRD1, CSF2RA, LAG3, FLVCR1, KLRB1, STX3, CD3G, PTPRM, GZMA, GPR171, NCF4, CD160, SIGLEC10, GZMB, BASP1, HLA-DQA1, NCR3, NPC1, TNFRSF10C, CCR3, RRAS2, PTGDR, CD226, HLA-DQB1, ENPP5, PRF1, GPRC5D, TNF, APH1A, FFAR2, CD247, ZBTB16, KCNJ2, ACSL1, IL12RB1, COL6A3, KLRF1, IL2RB, SMAD7, SYT11, PTPN4, ABCB1, CD180, TIGIT, P2RY13, TGFBR3, JAK2, RGS9, ALOX5, ARAP3, NKG7, GCA, F2R, FEZ1

3.88E-02