Table 4 The activated pathways and suppressed pathways enriched for the differentially expressed mRNAs (top 10 listed)

Up-regulated pathways

Natural killer cell mediated cytotoxicity

KLRC3, KLRD1, IFNG, GZMB, PRF1, NCR3, SH2D1A, CD247, NCR1, FASLG, PIK3R3, PPP3CC, CD244, HCST, ZAP70, KLRC4, FYN, KIR2DL1, PIK3R1, PLCG1, LCK, KIR3DL1, LAT

6.56E-03

Biosynthesis of unsaturated fatty acids

ELOVL6, ACOT7, TECR/ACOT4, SCD5, FADS2

6.56E-03

T cell receptor signaling pathway

IFNG, CD3G, CDC42, CD247, PTPRC, CD8A, PIK3R3, PPP3CC, MAPK13, CD3D, PRKCQ, AKT3, ITK, ZAP70, RASGRP1, FYN, GRAP2, PIK3R1, PDPK1, PLCG1, NFATC3, MAPK9, LCK, LAT, NCK2

6.56E-03

TH1 and TH2 cell differentiation

IFNG, CD3G, RUNX3, IL2RB, TBX21, STAT4, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL12RB2, IL2RG, MAPK9, LCK, LAT, DLL1, MAML3

6.56E-03

RNA degradation

PFKP, MPHOSPH6, PAPD5, HSPA9, DDX6, EXOSC2, LSM2, LSM5, TOB1, DCP1B, LSM1, TOB2, EXOSC7, LSM4, ENO2, DHX36, LSM8, CNOT3, PFKM, ZCCHC7, BTG1, LSM6, EXOSC3, LSM7, EXOSC1, PNPT1, EXOSC5, LSM3, DCPS

8.48E-03

Ribosome biogenesis in eukaryotes

LSG1, WDR36, AK6, WDR43, RIOK1, POP5, EMG1, RPP40, RAN, EIF6, NXT2, POP7, SPATA5, RBM28, GNL3L, NVL, GAR1, NHP2, BMS1, DROSHA, GNL2, FBL, XPO1, POP1/RCL1, NXT1, IMP4, UTP18, POP4, WDR3, CSNK2A2, NAT10

8.48E-03

TH17 cell differentiation

IFNG, RORA, CD3G, IL2RB, TBX21, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL2RG, MAPK9, LCK, LAT, IL21R

8.48E-03

Proteasome

IFNG, PSMD11, PSMD14, PSMB9, PSMD6, PSMA3, PSMB2, PSMA1, PSMA5, PSMA7, PSMB10, PSMB4, PSME1, PSMB6, PSMC2, PSMB5, PSMD2, PSMD8, PSME4, PSMC5, POMP, PSMD12, PSMA2, PSMB1

8.48E-03

Graft versus host disease

KLRD1, IFNG, GZMB, PRF1, FASLG, KIR2DL1

8.97E-03

Fatty acid elongation

ELOVL6, ACOT7, TECR, ACOT4, ELOVL7, ACAA2

1.14E-02

Down-regulated pathways

Leishmaniasis

MYD88, PTPN6, JAK1, ITGB1, CYBB, IL1A, TLR2, IRAK1, NCF2, TAB2, NCF1, IFNGR2, CR1, NCF4, JAK2, TNF, PTGS2, FCGR3B

6.56E-03

Legionellosis

NLRC4, CD14, CASP1, EEF1A2, TLR2, IL18, EEF1A1, HSPD1, APAF1, CR1, CXCL8, TNF, HSPA6, CXCL1

6.56E-03

Phagosome

TUBA1C, TUBA1A, THBS1, C3, CORO1A, ATP6V1C1, RAB5C, ITGB1, HGS, TUBB1, ATP6V1B2, CD36, THBS3, ATP6V0B, FCGR2B, MRC1, TUBB2A, CD14, ATP6V0C, THBS4, CYBB, RAB7A, TLR2, CLEC7A, ATP6V1A, ATP6V0D1, NCF2, TLR6, NCF1, FCAR, LAMP1, CTSS, NCF4, OLR1, FCGR3B, MPO

6.56E-03

Hematopoietic cell lineage

FCER2, CD1D, CD22, CD1C, CD4, CD37, CR2, CD19, CSF1R, IL3RA, CD36, IL11RA, CD14, IL9R, IL1A, ANPEP, MS4A1, CD9, CR1, IL1R1, CSF2RA, CD59, MME, TNF, CSF3R, IL1R2, CD24

6.56E-03

Tuberculosis

RAB5A, MAPK10, TLR9, RFXAP, RAB5B, FCER1G, IFNA7, SPHK2, CLEC4E, SYK, RAF1, ATP6AP1, CALML5, MAPK8, C3, FADD, MYD88, CEBPB, CORO1A, JAK1, RAB5C, CREB1, IL10RB, KSR1, LSP1, NOD2, ATP6V0B, FCGR2B, SPHK1, BCL10, MRC1, NFYC, IFNA17, CD14, CAMK2G, ATP6V0C, RAB7A, IL1A, TLR2, IL18, CLEC7A, EP300, TLR1, ATP6V0D1, IRAK1, CTSD, TLR6, HSPD1, IFNGR2, RHOA, LAMP1, APAF1, CR1, CTSS, JAK2, TNF, FCGR3B, CAMP

6.56E-03

Protein digestion and absorption

COL27A1, SLC6A19, SLC8A1, SLC7A7, KCNQ1, CELA3B, PRSS3, COL5A3, COL1A2, ATP1B1, COL9A3, SLC7A8, COL9A2, COL17A1, KCNE3, COL6A3, COL18A1, MME, CPA3

6.56E-03

Cytokine cytokine receptor interaction

CCR10, IL3RA, IL17RA, TNFSF13, IL19, CCL8, EGFR, IL11RA, OSM, CXCL12, CXCR5, IFNLR1, TNFRSF18, IL17RC, PRL, IFNA17, PLEKHO2, IL9R, IL17RB, IL1RAP, IL1A, IL18, HGF, VEGFA, CCR6, IFNGR2, TNFSF10, PF4V1, CXCL8, CCL20, TNFSF8, IL1R1, CSF2RA, CCL2, CCR9, CSF2RB, TNF, TNFRSF10C, CXCR2, CXCR1, CSF3R, CXCL1, IL1R2, TNFRSF17, CCR3

6.56E-03

Starch and sucrose metabolism

GBE1, G6PC2, GPI, GAA, HK3, G6PC3, PGM2L1, ENPP3, PYGL, MGAM

8.48E-03

Glycine serine and threonine metabolism

GAMT, PGAM2, AOC3, BPGM, AOC2, ALAS1, GLDC, ALAS2

8.48E-03

Amoebiasis

PRKACA, RAB5C, SERPINB10, LAMB2, LAMB3, GNAQ, COL1A2, CD14, PLCB2, RAB7A, TLR, LAMA5, ACTN1, CXCL8, IL1R1, TNF, CTSG, CXCL1, IL1R2, ARG1

8.48E-03