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Table 4 The activated pathways and suppressed pathways enriched for the differentially expressed mRNAs (top 10 listed)

From: Competing endogenous RNA network analysis explores the key lncRNAs, miRNAs, and mRNAs in type 1 diabetes

Description Normalized enrichment score Genes Adjusted p value
Up-regulated pathways
Natural killer cell mediated cytotoxicity 1.88803 KLRC3, KLRD1, IFNG, GZMB, PRF1, NCR3, SH2D1A, CD247, NCR1, FASLG, PIK3R3, PPP3CC, CD244, HCST, ZAP70, KLRC4, FYN, KIR2DL1, PIK3R1, PLCG1, LCK, KIR3DL1, LAT 6.56E-03
Biosynthesis of unsaturated fatty acids 1.989893 ELOVL6, ACOT7, TECR/ACOT4, SCD5, FADS2 6.56E-03
T cell receptor signaling pathway 2.006524 IFNG, CD3G, CDC42, CD247, PTPRC, CD8A, PIK3R3, PPP3CC, MAPK13, CD3D, PRKCQ, AKT3, ITK, ZAP70, RASGRP1, FYN, GRAP2, PIK3R1, PDPK1, PLCG1, NFATC3, MAPK9, LCK, LAT, NCK2 6.56E-03
TH1 and TH2 cell differentiation 2.137425 IFNG, CD3G, RUNX3, IL2RB, TBX21, STAT4, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL12RB2, IL2RG, MAPK9, LCK, LAT, DLL1, MAML3 6.56E-03
RNA degradation 1.717539 PFKP, MPHOSPH6, PAPD5, HSPA9, DDX6, EXOSC2, LSM2, LSM5, TOB1, DCP1B, LSM1, TOB2, EXOSC7, LSM4, ENO2, DHX36, LSM8, CNOT3, PFKM, ZCCHC7, BTG1, LSM6, EXOSC3, LSM7, EXOSC1, PNPT1, EXOSC5, LSM3, DCPS 8.48E-03
Ribosome biogenesis in eukaryotes 1.778302 LSG1, WDR36, AK6, WDR43, RIOK1, POP5, EMG1, RPP40, RAN, EIF6, NXT2, POP7, SPATA5, RBM28, GNL3L, NVL, GAR1, NHP2, BMS1, DROSHA, GNL2, FBL, XPO1, POP1/RCL1, NXT1, IMP4, UTP18, POP4, WDR3, CSNK2A2, NAT10 8.48E-03
TH17 cell differentiation 1.854181 IFNG, RORA, CD3G, IL2RB, TBX21, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL2RG, MAPK9, LCK, LAT, IL21R 8.48E-03
Proteasome 1.88607 IFNG, PSMD11, PSMD14, PSMB9, PSMD6, PSMA3, PSMB2, PSMA1, PSMA5, PSMA7, PSMB10, PSMB4, PSME1, PSMB6, PSMC2, PSMB5, PSMD2, PSMD8, PSME4, PSMC5, POMP, PSMD12, PSMA2, PSMB1 8.48E-03
Graft versus host disease 1.87728 KLRD1, IFNG, GZMB, PRF1, FASLG, KIR2DL1 8.97E-03
Fatty acid elongation 1.857462 ELOVL6, ACOT7, TECR, ACOT4, ELOVL7, ACAA2 1.14E-02
Down-regulated pathways
Leishmaniasis − 1.90122 MYD88, PTPN6, JAK1, ITGB1, CYBB, IL1A, TLR2, IRAK1, NCF2, TAB2, NCF1, IFNGR2, CR1, NCF4, JAK2, TNF, PTGS2, FCGR3B 6.56E-03
Legionellosis − 1.89969 NLRC4, CD14, CASP1, EEF1A2, TLR2, IL18, EEF1A1, HSPD1, APAF1, CR1, CXCL8, TNF, HSPA6, CXCL1 6.56E-03
Phagosome − 1.86804 TUBA1C, TUBA1A, THBS1, C3, CORO1A, ATP6V1C1, RAB5C, ITGB1, HGS, TUBB1, ATP6V1B2, CD36, THBS3, ATP6V0B, FCGR2B, MRC1, TUBB2A, CD14, ATP6V0C, THBS4, CYBB, RAB7A, TLR2, CLEC7A, ATP6V1A, ATP6V0D1, NCF2, TLR6, NCF1, FCAR, LAMP1, CTSS, NCF4, OLR1, FCGR3B, MPO 6.56E-03
Hematopoietic cell lineage − 1.7603 FCER2, CD1D, CD22, CD1C, CD4, CD37, CR2, CD19, CSF1R, IL3RA, CD36, IL11RA, CD14, IL9R, IL1A, ANPEP, MS4A1, CD9, CR1, IL1R1, CSF2RA, CD59, MME, TNF, CSF3R, IL1R2, CD24 6.56E-03
Tuberculosis − 1.74971 RAB5A, MAPK10, TLR9, RFXAP, RAB5B, FCER1G, IFNA7, SPHK2, CLEC4E, SYK, RAF1, ATP6AP1, CALML5, MAPK8, C3, FADD, MYD88, CEBPB, CORO1A, JAK1, RAB5C, CREB1, IL10RB, KSR1, LSP1, NOD2, ATP6V0B, FCGR2B, SPHK1, BCL10, MRC1, NFYC, IFNA17, CD14, CAMK2G, ATP6V0C, RAB7A, IL1A, TLR2, IL18, CLEC7A, EP300, TLR1, ATP6V0D1, IRAK1, CTSD, TLR6, HSPD1, IFNGR2, RHOA, LAMP1, APAF1, CR1, CTSS, JAK2, TNF, FCGR3B, CAMP 6.56E-03
Protein digestion and absorption − 1.70571 COL27A1, SLC6A19, SLC8A1, SLC7A7, KCNQ1, CELA3B, PRSS3, COL5A3, COL1A2, ATP1B1, COL9A3, SLC7A8, COL9A2, COL17A1, KCNE3, COL6A3, COL18A1, MME, CPA3 6.56E-03
Cytokine cytokine receptor interaction − 1.48441 CCR10, IL3RA, IL17RA, TNFSF13, IL19, CCL8, EGFR, IL11RA, OSM, CXCL12, CXCR5, IFNLR1, TNFRSF18, IL17RC, PRL, IFNA17, PLEKHO2, IL9R, IL17RB, IL1RAP, IL1A, IL18, HGF, VEGFA, CCR6, IFNGR2, TNFSF10, PF4V1, CXCL8, CCL20, TNFSF8, IL1R1, CSF2RA, CCL2, CCR9, CSF2RB, TNF, TNFRSF10C, CXCR2, CXCR1, CSF3R, CXCL1, IL1R2, TNFRSF17, CCR3 6.56E-03
Starch and sucrose metabolism − 1.89049 GBE1, G6PC2, GPI, GAA, HK3, G6PC3, PGM2L1, ENPP3, PYGL, MGAM 8.48E-03
Glycine serine and threonine metabolism − 1.80927 GAMT, PGAM2, AOC3, BPGM, AOC2, ALAS1, GLDC, ALAS2 8.48E-03
Amoebiasis − 1.70409 PRKACA, RAB5C, SERPINB10, LAMB2, LAMB3, GNAQ, COL1A2, CD14, PLCB2, RAB7A, TLR, LAMA5, ACTN1, CXCL8, IL1R1, TNF, CTSG, CXCL1, IL1R2, ARG1 8.48E-03