|
Up-regulated pathways
|
|
Natural killer cell mediated cytotoxicity
|
1.88803
|
KLRC3, KLRD1, IFNG, GZMB, PRF1, NCR3, SH2D1A, CD247, NCR1, FASLG, PIK3R3, PPP3CC, CD244, HCST, ZAP70, KLRC4, FYN, KIR2DL1, PIK3R1, PLCG1, LCK, KIR3DL1, LAT
|
6.56E-03
|
|
Biosynthesis of unsaturated fatty acids
|
1.989893
|
ELOVL6, ACOT7, TECR/ACOT4, SCD5, FADS2
|
6.56E-03
|
|
T cell receptor signaling pathway
|
2.006524
|
IFNG, CD3G, CDC42, CD247, PTPRC, CD8A, PIK3R3, PPP3CC, MAPK13, CD3D, PRKCQ, AKT3, ITK, ZAP70, RASGRP1, FYN, GRAP2, PIK3R1, PDPK1, PLCG1, NFATC3, MAPK9, LCK, LAT, NCK2
|
6.56E-03
|
|
TH1 and TH2 cell differentiation
|
2.137425
|
IFNG, CD3G, RUNX3, IL2RB, TBX21, STAT4, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL12RB2, IL2RG, MAPK9, LCK, LAT, DLL1, MAML3
|
6.56E-03
|
|
RNA degradation
|
1.717539
|
PFKP, MPHOSPH6, PAPD5, HSPA9, DDX6, EXOSC2, LSM2, LSM5, TOB1, DCP1B, LSM1, TOB2, EXOSC7, LSM4, ENO2, DHX36, LSM8, CNOT3, PFKM, ZCCHC7, BTG1, LSM6, EXOSC3, LSM7, EXOSC1, PNPT1, EXOSC5, LSM3, DCPS
|
8.48E-03
|
|
Ribosome biogenesis in eukaryotes
|
1.778302
|
LSG1, WDR36, AK6, WDR43, RIOK1, POP5, EMG1, RPP40, RAN, EIF6, NXT2, POP7, SPATA5, RBM28, GNL3L, NVL, GAR1, NHP2, BMS1, DROSHA, GNL2, FBL, XPO1, POP1/RCL1, NXT1, IMP4, UTP18, POP4, WDR3, CSNK2A2, NAT10
|
8.48E-03
|
|
TH17 cell differentiation
|
1.854181
|
IFNG, RORA, CD3G, IL2RB, TBX21, IL12RB1, CD247, PPP3CC, MAPK13, CD3D, PRKCQ, ZAP70, GATA3, PLCG1, NFATC3, IL2RG, MAPK9, LCK, LAT, IL21R
|
8.48E-03
|
|
Proteasome
|
1.88607
|
IFNG, PSMD11, PSMD14, PSMB9, PSMD6, PSMA3, PSMB2, PSMA1, PSMA5, PSMA7, PSMB10, PSMB4, PSME1, PSMB6, PSMC2, PSMB5, PSMD2, PSMD8, PSME4, PSMC5, POMP, PSMD12, PSMA2, PSMB1
|
8.48E-03
|
|
Graft versus host disease
|
1.87728
|
KLRD1, IFNG, GZMB, PRF1, FASLG, KIR2DL1
|
8.97E-03
|
|
Fatty acid elongation
|
1.857462
|
ELOVL6, ACOT7, TECR, ACOT4, ELOVL7, ACAA2
|
1.14E-02
|
|
Down-regulated pathways
|
|
Leishmaniasis
|
− 1.90122
|
MYD88, PTPN6, JAK1, ITGB1, CYBB, IL1A, TLR2, IRAK1, NCF2, TAB2, NCF1, IFNGR2, CR1, NCF4, JAK2, TNF, PTGS2, FCGR3B
|
6.56E-03
|
|
Legionellosis
|
− 1.89969
|
NLRC4, CD14, CASP1, EEF1A2, TLR2, IL18, EEF1A1, HSPD1, APAF1, CR1, CXCL8, TNF, HSPA6, CXCL1
|
6.56E-03
|
|
Phagosome
|
− 1.86804
|
TUBA1C, TUBA1A, THBS1, C3, CORO1A, ATP6V1C1, RAB5C, ITGB1, HGS, TUBB1, ATP6V1B2, CD36, THBS3, ATP6V0B, FCGR2B, MRC1, TUBB2A, CD14, ATP6V0C, THBS4, CYBB, RAB7A, TLR2, CLEC7A, ATP6V1A, ATP6V0D1, NCF2, TLR6, NCF1, FCAR, LAMP1, CTSS, NCF4, OLR1, FCGR3B, MPO
|
6.56E-03
|
|
Hematopoietic cell lineage
|
− 1.7603
|
FCER2, CD1D, CD22, CD1C, CD4, CD37, CR2, CD19, CSF1R, IL3RA, CD36, IL11RA, CD14, IL9R, IL1A, ANPEP, MS4A1, CD9, CR1, IL1R1, CSF2RA, CD59, MME, TNF, CSF3R, IL1R2, CD24
|
6.56E-03
|
|
Tuberculosis
|
− 1.74971
|
RAB5A, MAPK10, TLR9, RFXAP, RAB5B, FCER1G, IFNA7, SPHK2, CLEC4E, SYK, RAF1, ATP6AP1, CALML5, MAPK8, C3, FADD, MYD88, CEBPB, CORO1A, JAK1, RAB5C, CREB1, IL10RB, KSR1, LSP1, NOD2, ATP6V0B, FCGR2B, SPHK1, BCL10, MRC1, NFYC, IFNA17, CD14, CAMK2G, ATP6V0C, RAB7A, IL1A, TLR2, IL18, CLEC7A, EP300, TLR1, ATP6V0D1, IRAK1, CTSD, TLR6, HSPD1, IFNGR2, RHOA, LAMP1, APAF1, CR1, CTSS, JAK2, TNF, FCGR3B, CAMP
|
6.56E-03
|
|
Protein digestion and absorption
|
− 1.70571
|
COL27A1, SLC6A19, SLC8A1, SLC7A7, KCNQ1, CELA3B, PRSS3, COL5A3, COL1A2, ATP1B1, COL9A3, SLC7A8, COL9A2, COL17A1, KCNE3, COL6A3, COL18A1, MME, CPA3
|
6.56E-03
|
|
Cytokine cytokine receptor interaction
|
− 1.48441
|
CCR10, IL3RA, IL17RA, TNFSF13, IL19, CCL8, EGFR, IL11RA, OSM, CXCL12, CXCR5, IFNLR1, TNFRSF18, IL17RC, PRL, IFNA17, PLEKHO2, IL9R, IL17RB, IL1RAP, IL1A, IL18, HGF, VEGFA, CCR6, IFNGR2, TNFSF10, PF4V1, CXCL8, CCL20, TNFSF8, IL1R1, CSF2RA, CCL2, CCR9, CSF2RB, TNF, TNFRSF10C, CXCR2, CXCR1, CSF3R, CXCL1, IL1R2, TNFRSF17, CCR3
|
6.56E-03
|
|
Starch and sucrose metabolism
|
− 1.89049
|
GBE1, G6PC2, GPI, GAA, HK3, G6PC3, PGM2L1, ENPP3, PYGL, MGAM
|
8.48E-03
|
|
Glycine serine and threonine metabolism
|
− 1.80927
|
GAMT, PGAM2, AOC3, BPGM, AOC2, ALAS1, GLDC, ALAS2
|
8.48E-03
|
|
Amoebiasis
|
− 1.70409
|
PRKACA, RAB5C, SERPINB10, LAMB2, LAMB3, GNAQ, COL1A2, CD14, PLCB2, RAB7A, TLR, LAMA5, ACTN1, CXCL8, IL1R1, TNF, CTSG, CXCL1, IL1R2, ARG1
|
8.48E-03
|
