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Table 1 A hypothetical example of the negative data problem

From: An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

Mutations Biopsy (#1) Biopsy (#2)
Read counts (mutant/total) VAF (%) Status Read counts (mutant/total) VAF (%) Status #1 (UMC 20X) Status #2 (MSN)
EGFR (T790M) 40/72 56 Positive 0/15 0 Unknown Negative
EGFR (C797S) 5/100 5 Positive 0/30 0 Negative Unknown