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Table 1 Chromosomal aberrations in hepatocellular carcinoma (HCC) tumours compared to adjacent non-tumourous tissues (NT)

From: Gene networks and transcriptional regulators associated with liver cancer development and progression

Chr

Arm

Type of aberration

Significanta

Non-neoplastic tissues (NT)

HCC

NT

HCC

Sizeb of intervals

% cases affected

Sizeb of intervals

% cases affected

1

p

Loss

Yes

0

0

407

27.3–31.8

1

q

Gain

Yes

2108

7.7–23.1

2108

54.5–77.3

2

q

Gain

Yes

0

0

206

27.336.4

3

p

Gain

Yes

173

15.4–23.1

173

54.573.6

4

q

Loss

Yes

0

0

689

27.3–31.8

5

p

Gain

Yes

0

0

12

27.3

5

q

Loss

Yes

0

0

673

27.331.8

5

q

Gain

Yes

0

0

154

27.3

6

p

Gain

Yes

525

7.7–15.4

1061

31.8–68.2

6

q

Loss

Yes

0

0

26

27.3

7

p

Gain

Yes

100

7.7–15.4

810

27.3–68.2

7

q

Gain

Gain

Yes

96

23.1–30.8

146

36.4–72.7

7

q

Gain

Gain

No

94

30.7–53.8

94

63.6–72.7

8

p

Loss

Yes

103

7.7

525

31.8–63.6

8

q

Gain

Yes

14

7.7

1456

27.3–50

8

q

Gain

Gain

Yes

22

46.2

22

81.8

8

q

Gain

Gain

No

54

38.4–69.2

54

72.7–81.8

9

q

Gain

Yes

10

15.4

10

63.6

9

q

Gain

Gain

No

276

30.7

276

63.6

10

q

Gain

Yes

12

7.7

51

27.3–50

10

q

Loss

Yes

0

0

13

27.3

11

q

Gain

Gain

Yes

80

38.5

80

77.3

11

p/q

Gain

Gain

No

373

38.4–53.8

373

59.1–72.7

12

p

Gain

Yes

0

0

38

36.4

12

q

Gain

Yes

323

15.4

323

54.5–63.6

13

q

Loss

Yes

23

7.7

996

27.3–50.0

13

q

Gain

Yes

21

7.7

21

45.5–50.0

14

q

Gain

Yes

158

7.7–23.1

158

45.5–59.1

15

q

Gain

Yes

38

15.4

498

27.3–54.5

16

p

Gain

Yes

221

7.7

221

40.9–50.5

16

q

Loss

Yes

15

7.7

15

31.8

17

p/q

Gain

Yes

1802

7.7–15.4

1802

40.9–63.6

18

q

Loss

Yes

0

0

759

27.3–36.4

19

q

Gain

Yes

10

7.7

10

45.5

19

p

Gain

Gain

No

652

53.8

652

68.2–77.3

19

q

Gain

Gain

No

999

30.8–46.2

999

63.6–68.2

20

p/q

Gain

Yes

820

7.7–23.1

1125

31.8–63.6

21

q

Gain

Yes

0

0

235

27.3–36.4

22

q

Gain

Yes

810

7.7–15.4

810

59.1–63.6

  1. The table only includes aberrations that spanned more than 10 probes. Known chromosomal imbalances in HCC are marked in bold. Common aberrations found in both HCC (n = 22) and adjacent NT (n = 17) samples were included when they affected > 50% of cases in one tissue set and > 30% of cases in the other; they are presented in italics
  2. Chr chromosome
  3. aDifferential aberrations between HCC and NT samples were considered statistically significant when P < 0.05 in differential aberration analysis
  4. bThe interval size is expressed as the total number of probes that spanned the aberration interval