|
Gene
|
Chr locus
|
Amplified in GE1-HCC, %
|
Amplified in GE2-HCC, %
|
Amplified in NT, %
|
Mean fold changea of gene expression in GE1-HCC versus NT
|
Mean fold changea of gene expression in GE2-HCC versus NT
|
|---|
|
C1orf35
|
1q42.13
|
80
|
75
|
15.4
|
2.15
|
2.4
|
|
HIST2 cluster
|
1q21
|
80
|
75
|
15.4
|
No change
|
2.8–22.2
|
|
PARP1
|
1q42.12
|
70
|
66.7
|
15.4
|
No change
|
2.06
|
|
KPNA2
|
17q24.2
|
50
|
75
|
7.7
|
No change
|
2.63
|
|
BIRC5
|
17q25.3
|
50
|
75
|
7.7
|
3.41
|
34.5
|
|
TK1
|
17q25.3
|
50
|
75
|
7.7
|
1.69
|
6.93
|
|
E2F1
|
20q11.2
|
60
|
66.7
|
15.4
|
1.97
|
6.43
|
|
KIFC1
|
6p21.3
|
60
|
66.7
|
15.4
|
No change
|
9.44
|
|
HIST1 cluster
|
6p21-6p22
|
60
|
66.7
|
15.4
|
No change
|
2.6–15.9
|
|
UBE2C
|
20q13.12
|
60
|
66.7
|
15.4
|
1.64
|
20.35
|
|
RECQL4
|
8q24
|
100
|
66.7
|
69.2
|
2.12
|
6.7
|
|
H19
|
11p15.5
|
80
|
41.7
|
53.8
|
− 3.06
|
4.58
|
|
SNAR-A3
|
19q13.33
|
90
|
50
|
46.2
|
No change
|
7.72
|
|
SNAR-B2
|
19q13.33
|
90
|
50
|
46.2
|
No change
|
15.83
|
|
SNAR-D
|
19q13.33
|
90
|
50
|
46.2
|
No change
|
17.5
|
|
SNAR-G2
|
19q13.33
|
90
|
50
|
46.2
|
No change
|
17.45
|
|
ILF3
|
19q13.2
|
90
|
50
|
46.2
|
No change
|
2.21
|
|
PAFAH1B3
|
19q13.1
|
90
|
50
|
46.2
|
No change
|
3.85
|
- Chr chromosome, HCC hepatocellular carcinoma, NT non-tumourous
- aOnly statistically significant fold changes are shown
