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Table 3 Selected upregulated genes with oncogenic functions located in amplified chromosomal regions

From: Gene networks and transcriptional regulators associated with liver cancer development and progression

Gene Chr locus Amplified in GE1-HCC, % Amplified in GE2-HCC, % Amplified in NT, % Mean fold changea of gene expression in GE1-HCC versus NT Mean fold changea of gene expression in GE2-HCC versus NT
C1orf35 1q42.13 80 75 15.4 2.15 2.4
HIST2 cluster 1q21 80 75 15.4 No change 2.8–22.2
PARP1 1q42.12 70 66.7 15.4 No change 2.06
KPNA2 17q24.2 50 75 7.7 No change 2.63
BIRC5 17q25.3 50 75 7.7 3.41 34.5
TK1 17q25.3 50 75 7.7 1.69 6.93
E2F1 20q11.2 60 66.7 15.4 1.97 6.43
KIFC1 6p21.3 60 66.7 15.4 No change 9.44
HIST1 cluster 6p21-6p22 60 66.7 15.4 No change 2.6–15.9
UBE2C 20q13.12 60 66.7 15.4 1.64 20.35
RECQL4 8q24 100 66.7 69.2 2.12 6.7
H19 11p15.5 80 41.7 53.8 − 3.06 4.58
SNAR-A3 19q13.33 90 50 46.2 No change 7.72
SNAR-B2 19q13.33 90 50 46.2 No change 15.83
SNAR-D 19q13.33 90 50 46.2 No change 17.5
SNAR-G2 19q13.33 90 50 46.2 No change 17.45
ILF3 19q13.2 90 50 46.2 No change 2.21
PAFAH1B3 19q13.1 90 50 46.2 No change 3.85
  1. Chr chromosome, HCC hepatocellular carcinoma, NT non-tumourous
  2. aOnly statistically significant fold changes are shown