Table 3 Selected upregulated genes with oncogenic functions located in amplified chromosomal regions
Gene | Chr locus | Amplified in GE1-HCC, % | Amplified in GE2-HCC, % | Amplified in NT, % | Mean fold changea of gene expression in GE1-HCC versus NT | Mean fold changea of gene expression in GE2-HCC versus NT |
|---|---|---|---|---|---|---|
C1orf35 | 1q42.13 | 80 | 75 | 15.4 | 2.15 | 2.4 |
HIST2 cluster | 1q21 | 80 | 75 | 15.4 | No change | 2.8–22.2 |
PARP1 | 1q42.12 | 70 | 66.7 | 15.4 | No change | 2.06 |
KPNA2 | 17q24.2 | 50 | 75 | 7.7 | No change | 2.63 |
BIRC5 | 17q25.3 | 50 | 75 | 7.7 | 3.41 | 34.5 |
TK1 | 17q25.3 | 50 | 75 | 7.7 | 1.69 | 6.93 |
E2F1 | 20q11.2 | 60 | 66.7 | 15.4 | 1.97 | 6.43 |
KIFC1 | 6p21.3 | 60 | 66.7 | 15.4 | No change | 9.44 |
HIST1 cluster | 6p21-6p22 | 60 | 66.7 | 15.4 | No change | 2.6–15.9 |
UBE2C | 20q13.12 | 60 | 66.7 | 15.4 | 1.64 | 20.35 |
RECQL4 | 8q24 | 100 | 66.7 | 69.2 | 2.12 | 6.7 |
H19 | 11p15.5 | 80 | 41.7 | 53.8 | − 3.06 | 4.58 |
SNAR-A3 | 19q13.33 | 90 | 50 | 46.2 | No change | 7.72 |
SNAR-B2 | 19q13.33 | 90 | 50 | 46.2 | No change | 15.83 |
SNAR-D | 19q13.33 | 90 | 50 | 46.2 | No change | 17.5 |
SNAR-G2 | 19q13.33 | 90 | 50 | 46.2 | No change | 17.45 |
ILF3 | 19q13.2 | 90 | 50 | 46.2 | No change | 2.21 |
PAFAH1B3 | 19q13.1 | 90 | 50 | 46.2 | No change | 3.85 |