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Table 9 Candidate molecules for targeted anti-tumour therapy in GE1-HCC and GE2-HCC

From: Gene networks and transcriptional regulators associated with liver cancer development and progression

Analyses predicting the candidate gene

Target molecule in GE1-HCC

Target molecule in GE2-HCC

Selectivity suggested for cancer cells

References to targeted therapy approaches under investigation/development

GE, MR, TR

E2F1

E2F1

 

[132]

GE

MDK

MDK

Yes

[73]

GE

BIRC5

BIRC5

Yes

[133]

GE

GPC3

GPC3

Yes

[92]

GE

KIFC1

Yes

[134]

GE

PARP1

Yes

[109]

GE, MR

PKMYT1

Yes

[119, 120]

GE

 

PEG10

 

[95]

MR, GE

SOCS3

 

[135]

MR

IL10

IL10

Yes

[136]

MR

TNF

 

[137]

TR

AR

 

[24]

TR

PGR

PGR

 

[27]

TR

POU2F1

Yes

[126]

TR

NFY

 

[57]

TR

TFCP2

TFCP2

 

[131]