Gene networks and transcriptional regulators associated with liver cancer development and progression

BMC Medical Genomics

Table 9 Candidate molecules for targeted anti-tumour therapy in GE1-HCC and GE2-HCC

Analyses predicting the candidate gene	Target molecule in GE1-HCC	Target molecule in GE2-HCC	Selectivity suggested for cancer cells	References to targeted therapy approaches under investigation/development
GE, MR, TR	E2F1	E2F1		[132]
GE	MDK	MDK	Yes	[73]
GE	BIRC5	BIRC5	Yes	[133]
GE	GPC3	GPC3	Yes	[92]
GE	–	KIFC1	Yes	[134]
GE	–	PARP1	Yes	[109]
GE, MR	–	PKMYT1	Yes	[119, 120]
GE		PEG10		[95]
MR, GE	SOCS3	–		[135]
MR	IL10	IL10	Yes	[136]
MR	–	TNF		[137]
TR	AR	–		[24]
TR	PGR	PGR		[27]
TR	–	POU2F1	Yes	[126]
TR	–	NFY		[57]
TR	TFCP2	TFCP2		[131]

ISSN: 1755-8794