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Table 1 Odds ratios (OR) and 95% confidence intervals (CI) of the genetically predicted lifestyle factors with COVID-19 severe illness

From: Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study

Lifestyle factor Number of variants Severe respiratory COVID-19 COVID-19 hospitalization
OR (95% CI) P OR (95% CI) P
Body mass index 656 1.91 (1.55, 2.35) 7.4 × 10–10 1.75 (1.52, 2.01) 9.0 × 10–15
Lifetime smoking 126 1.84 (1.08, 3.13) 0.02 2.15 (1.52, 3.03) 1.5 × 10–05
Physical activity 5 0.19 (0.05, 0.74) 0.02 0.44 (0.18, 1.07) 0.07
Alcohol consumption: all variants 80 1.64 (0.70, 3.81) 0.25 1.57 (0.90, 2.73) 0.11
Alcohol consumption: rs1229984, rs2532276 removed 78 0.64 (0.25, 1.64) 0.35 1.11 (0.57, 2.17) 0.76
  1. OR and 95% CI were expressed as per standard deviation increase in genetically predicted levels in body mass index, lifetime smoking, accelerometer-measured physical activity and alcohol consumption (log-transformed standard drinks per week)