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Table 2 Heterogeneity test results for the genetic variants

From: Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study

Lifestyle factor Method Q df P
Severe respiratory COVID-19
Body mass index Inverse variance weighted 776.073 655 7.4 × 10–04
Body mass index MR-Egger 770.065 654 1.1 × 10–03
Lifetime smoking Inverse variance weighted 137.387 125 0.21
Lifetime smoking MR-Egger 137.335 124 0.19
Physical activity Inverse variance weighted 3.273 4 0.51
Physical activity MR-Egger 3.005 3 0.39
Alcohol consumption: all variants Inverse variance weighted 118.041 79 2.9 × 10–03
Alcohol consumption: all variants MR-Egger 110.051 78 0.01
Alcohol consumption: rs1229984, rs2532276 removed Inverse variance weighted 99.353 77 0.04
Alcohol consumption: rs1229984, rs2532276 removed MR-Egger 99.280 76 0.04
COVID-19 hospitalization
Body mass index Inverse variance weighted 772.906 655 9.7 × 10–04
Body mass index MR-Egger 771.083 654 1.0 × 10–03
Lifetime smoking Inverse variance weighted 131.212 125 0.33
Lifetime smoking MR-Egger 131.192 124 0.31
Physical activity Inverse variance weighted 3.629 4 0.46
Physical activity MR-Egger 1.852 3 0.60
Alcohol consumption: all variants Inverse variance weighted 117.782 79 3.1 × 10–03
Alcohol consumption: all variants MR-Egger 115.557 78 3.7 × 10–03
Alcohol consumption: rs1229984, rs2532276 removed Inverse variance weighted 108.280 77 0.01
Alcohol consumption: rs1229984, rs2532276 removed MR-Egger 108.188 76 0.01