Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study

BMC Medical Genomics

Table 2 Heterogeneity test results for the genetic variants

Lifestyle factor	Method	Q	df	P
Severe respiratory COVID-19
Body mass index	Inverse variance weighted	776.073	655	7.4 × 10^–04
Body mass index	MR-Egger	770.065	654	1.1 × 10^–03
Lifetime smoking	Inverse variance weighted	137.387	125	0.21
Lifetime smoking	MR-Egger	137.335	124	0.19
Physical activity	Inverse variance weighted	3.273	4	0.51
Physical activity	MR-Egger	3.005	3	0.39
Alcohol consumption: all variants	Inverse variance weighted	118.041	79	2.9 × 10^–03
Alcohol consumption: all variants	MR-Egger	110.051	78	0.01
Alcohol consumption: rs1229984, rs2532276 removed	Inverse variance weighted	99.353	77	0.04
Alcohol consumption: rs1229984, rs2532276 removed	MR-Egger	99.280	76	0.04
COVID-19 hospitalization
Body mass index	Inverse variance weighted	772.906	655	9.7 × 10^–04
Body mass index	MR-Egger	771.083	654	1.0 × 10^–03
Lifetime smoking	Inverse variance weighted	131.212	125	0.33
Lifetime smoking	MR-Egger	131.192	124	0.31
Physical activity	Inverse variance weighted	3.629	4	0.46
Physical activity	MR-Egger	1.852	3	0.60
Alcohol consumption: all variants	Inverse variance weighted	117.782	79	3.1 × 10^–03
Alcohol consumption: all variants	MR-Egger	115.557	78	3.7 × 10^–03
Alcohol consumption: rs1229984, rs2532276 removed	Inverse variance weighted	108.280	77	0.01
Alcohol consumption: rs1229984, rs2532276 removed	MR-Egger	108.188	76	0.01

ISSN: 1755-8794