Fig.1

Assessing the differentially expressed mRNAs and proteins of NP cells in intervertebral disc degeneration. The unsupervised Hierarchical cluster plot of the label-free proteomic sequencing data (a) or RNA sequencing data (c) showing the differentially expressed proteins (a) or mRNAs (c) of NP cells from IVD and IDD groups. The green color indicates relatively lower expression of each gene, while the red color indicates higher expression. The volcano plot showing the degree of fold changes of each gene’s protein (b) or mRNA (d) expression in NP cells between IVD and IDD groups. e A Venn plot showing the number of genes that have significant changes in either protein level, mRNA level or both. f The list of the overlapped genes that are significantly changed during disc degeneration