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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Identification of monocyte-associated genes as predictive biomarkers of heart failure after acute myocardial infarction

Fig. 4

Identifying recruited monocytes/monocytes-derived macrophages cluster (CCR2+ monocytes/macrophages) in the infarcted cardiac tissue of mice. a UMAP visualization of cell clusters present in pooled control and post-AMI samples. CCR2+ monocytes/macrophages were identified as cluster 4. b UMAP plot depicting all cell types in control (blue) and MI samples (yellow). c Dot plot of marker genes for each macrophage cluster. Dot size represents the percentage of cells expressing the marker gene in each cell cluster. The color scale reflects the gene expression level from low to high. d Heatmap of top 20 differently expressed genes (10 upregulated and 10 downregulated genes) in CCR2+ monocytes/macrophages between AMI and control mice. The color scale indicates the gene expression level (blue: low; red: high). UMAP: Uniform Manifold Approximation and Projection

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