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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Determining mutational burden and signature using RNA-seq from tumor-only samples

Fig. 3

Mutational signatures from filtered UCEC variants. ac COSMIC mutational signatures of MSS (natural aging, signature 5), MSI-H (signature 6), and POLɛ (signature 10). df Filtered UCEC variant derived signatures for MSS, MSI-H, and POLɛ. g MSS and MSI-H samples regressed against the germline signature derived from dbSNP variants. h MSS and MSI-H samples regressed against COSMIC MSI-H signature. Significance from t-test, p-value < 0.01. POLɛ and non-POLɛ samples regressed against COSMIC POLɛ signature. Significance from t-test, p-value < 0.001)

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